Schroeder S A, Shannon D C, Mark E J
New York Medical College, Valhalla 10591.
Chest. 1992 Apr;101(4):1065-9. doi: 10.1378/chest.101.4.1065.
Five infants had interstitial pneumonitis with constant histologic findings, which was different from that previously described in children. All the infants presented with tachypnea at birth and persistent disease, both clinically and radiographically, despite treatment. Open-lung biopsy in each case showed a diffuse interstitial thickening due to pale oval and spindle-shaped histiocytes without scarring. This neonatal cellular interstitial pneumonitis differs both clinically and histologically from the usual interstitial pneumonitis, lymphocytic interstitial pneumonitis and desquamative interstitial pneumonitis observed in adults and children. The etiology of this cellular interstitial pneumonitis in neonates is unknown.
五名婴儿患有间质性肺炎，组织学表现持续存在，这与之前儿童中所描述的不同。所有婴儿出生时均表现为呼吸急促，且尽管接受了治疗，但在临床和影像学上疾病仍持续存在。每例经开放式肺活检均显示，由于苍白的椭圆形和梭形组织细胞导致弥漫性间质增厚，无瘢痕形成。这种新生儿细胞性间质性肺炎在临床和组织学上均不同于在成人和儿童中观察到的常见间质性肺炎、淋巴细胞性间质性肺炎和脱屑性间质性肺炎。新生儿这种细胞性间质性肺炎的病因尚不清楚。
