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Angiotensin-converting enzyme inhibitors in patients with bronchial responsiveness and asthma.

作者信息

Kaufman J, Schmitt S, Barnard J, Busse W

机构信息

Medical College of Wisconsin, Milwaukee.

出版信息

Chest. 1992 Apr;101(4):922-5. doi: 10.1378/chest.101.4.922.

DOI:10.1378/chest.101.4.922
PMID:1555463
Abstract

Twenty-one subjects with known bronchial hyperreactivity were prospectively randomized in double-blind fashion to receive one of two angiotensin-converting enzyme inhibitors (ACE-I), enalapril or spirapril, for three weeks. Spirometry and methacholine provocation were performed prior to, during, and following ACE-I usage. Three of 21 subjects developed a nonproductive cough. However, only one subject wheezed slightly. Spirometry and bronchial reactivity (PD20) were unchanged throughout the study.

摘要

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