药物性咳嗽。
Drug-Induced Cough.
机构信息
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul,
出版信息
Physiol Res. 2020 Mar 27;69(Suppl 1):S81-S92. doi: 10.33549/physiolres.934406.
Abstract
Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs in patients with chronic cough. The focus is placed on ACEIs, for which there are a multitude of studies documenting their associations with cough. Additional drugs are discussed for which there are reports of cough as a side effect of treatment, and the potential mechanisms of these effects are discussed.
摘要
自发现血管紧张素转换酶抑制剂（ACEI）可引起咳嗽以来，人们一直认为该药物是导致慢性咳嗽的潜在原因。本综述介绍了目前有关慢性咳嗽患者药物性咳嗽的最新知识。重点介绍了 ACEI，因为有大量研究证明其与咳嗽有关。此外，还讨论了一些报告显示治疗过程中会出现咳嗽副作用的其他药物，并讨论了这些影响的潜在机制。
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Physiol Res. 2020 Mar 27;69(Suppl 1):S81-S92. doi: 10.33549/physiolres.934406.
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本文引用的文献
1
ERS guidelines on the diagnosis and treatment of chronic cough in adults and children.ERS 指南：成人和儿童慢性咳嗽的诊断与治疗。
Eur Respir J. 2020 Jan 2;55(1). doi: 10.1183/13993003.01136-2019. Print 2020 Jan.
2
The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1).神经激肽-1 受体拮抗剂奥维替班是一种治疗慢性难治性咳嗽的新型镇咳治疗药物：来自 2 期先导研究（VOLCANO-1）的结果。
Chest. 2020 Jan;157(1):111-118. doi: 10.1016/j.chest.2019.08.001. Epub 2019 Aug 14.
3
Chronic cough in the elderly.老年人慢性咳嗽。
Pulm Pharmacol Ther. 2019 Jun;56:63-68. doi: 10.1016/j.pupt.2019.03.010. Epub 2019 Mar 23.
4
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Turk Thorac J. 2019 Jan 1;20(1):36-42. doi: 10.5152/TurkThoracJ.2018.18014.
5
KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea.韩国成人及儿童慢性咳嗽的KAAACI循证临床实践指南
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6
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Br J Pharmacol. 2019 Apr;176(8):1051-1058. doi: 10.1111/bph.14327. Epub 2018 May 17.
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Clin Pharmacol Ther. 2019 Mar;105(3):652-660. doi: 10.1002/cpt.1018. Epub 2018 Feb 8.
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