边缘性红斑与遗传性血管性水肿。
Erythema marginatum and hereditary angioedema.
作者信息
Starr John C, Brasher George W, Rao Arundhati, Posey Delma
机构信息
Division of Allergy & Immunology, Department of Pathology, Scott & White, Scott, Sherwood, TX, USA.
出版信息
South Med J. 2004 Oct;97(10):948-50. doi: 10.1097/01.SMJ.0000140850.22535.FA.
OBJECTIVE
To search for anaphylatoxin activity in plasma during episodes of erythema marginatum, and to evaluate the histology of erythema marginatum by electron microscopy and immunohistologic techniques.
METHODS
Plasma samples were studied for C5a activity by granulocyte aggregation, and C3 conversion by immunoelectrophoresis. A skin biopsy of erythema marginatum was done, and the tissue stained with a rabbit antibody to bradykinin.
RESULTS
No plasma anaphylatoxin was found. Dense deposits of bradykinin were discovered in stromal tissue and lining endothelial cells.
CONCLUSIONS
Bradykinin may be important in the causality of the erythema marginatum associated with hereditary angioedema.
目的
在边缘性红斑发作期间检测血浆中的过敏毒素活性，并通过电子显微镜和免疫组织学技术评估边缘性红斑的组织学特征。
方法
通过粒细胞聚集研究血浆样本中的C5a活性，并通过免疫电泳研究C3转化。对边缘性红斑进行皮肤活检，并用抗缓激肽兔抗体对组织进行染色。
结果
未发现血浆过敏毒素。在间质组织和衬里内皮细胞中发现了大量缓激肽沉积物。
结论
缓激肽可能在与遗传性血管性水肿相关的边缘性红斑的病因中起重要作用。
Zotero 插件