Frey Danielle J, Badia Pietro, Wright Kenneth P
Sleep and Chronobiology Laboratory, Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA.
J Sleep Res. 2004 Dec;13(4):305-15. doi: 10.1111/j.1365-2869.2004.00429.x.
The study purpose was to assess inter- and intra-individual variability in neurobehavioral function near the circadian nadir during sleep deprivation and conduct exploratory factor analyses to assess relationships among alertness and performance measures during sleep deprivation. Twenty-five healthy individuals (16 females) aged 18-25 years participated. Participants were sleep deprived for two nights under controlled laboratory conditions using a modified constant routine procedure. A comprehensive battery of neurobehavioral performance tests, subjective sleepiness (SSS), and objective alertness (MWT) were assessed. Seventeen of the 22 neurobehavioral measures were impaired by sleep deprivation (all P < 0.01). The use of multiple neurobehavioral performance measures revealed impairments for all individuals during sleep deprivation. However, sleep deprivation effects were task dependent within and between individuals. Gender contributed minimally to inter-individual variability in performance. Exploratory factor analysis reduced the 22 measures to seven independent factors. Our findings indicate that no individual was especially vulnerable or resistant to the performance impairing effects of sleep deprivation. Instead, inter- and intra-individual variability in performance during sleep deprivation was task dependent. The finding that subjective sleepiness and objective alertness were not related to any performance measure during sleep deprivation suggests that these measures may assess independent brain functions.
本研究的目的是评估睡眠剥夺期间昼夜节律最低点附近神经行为功能的个体间和个体内变异性，并进行探索性因素分析，以评估睡眠剥夺期间警觉性和表现指标之间的关系。25名年龄在18至25岁之间的健康个体（16名女性）参与了研究。参与者在实验室控制条件下，采用改良的固定日常程序被剥夺睡眠两晚。评估了一系列全面的神经行为表现测试、主观嗜睡（SSS）和客观警觉性（MWT）。22项神经行为指标中有17项因睡眠剥夺而受损（所有P<0.01）。使用多种神经行为表现指标揭示了睡眠剥夺期间所有个体均出现功能受损。然而，睡眠剥夺的影响在个体内部和个体之间都取决于任务。性别对个体间表现变异性的贡献最小。探索性因素分析将22项指标减少为7个独立因素。我们的研究结果表明，没有个体对睡眠剥夺的表现损害效应特别敏感或有抵抗力。相反，睡眠剥夺期间表现的个体间和个体内变异性取决于任务。睡眠剥夺期间主观嗜睡和客观警觉性与任何表现指标均无关联这一发现表明，这些指标可能评估的是独立的脑功能。
