Galliaud Elodie, Taillard Jacques, Sagaspe Patricia, Valtat Cédric, Bioulac Bernard, Philip Pierre
GENPPHASS, CHU Pellegrin, Bordeaux, France.
J Sleep Res. 2008 Mar;17(1):11-5. doi: 10.1111/j.1365-2869.2008.00629.x.
While sleep restriction decreases performance, not all individuals are equal with regard to sensitivity to sleep loss. We tested the hypothesis that performance could be independent of sleep pressure as defined by EEG alpha-theta power. Twenty healthy subjects (10 vulnerable and 10 resistant) underwent sleep deprivation for 25 h. Subjects had to rate their sleepiness (Karolinska Sleepiness Scale) and to perform a 10-min psychomotor vigilance task (PVT) every 2 h (20:00-08:00 hours). Sleep pressure was measured by EEG power spectral analysis (alpha-theta band 6.0-9.0 Hz). Initial performance, EEG spectral power and KSS score were equal in both groups (ANOVA, NS). The performance of vulnerable subjects significantly increased during the night (rANOVA, P < 0.01), whereas resistant subjects globally sustained their performance. Homeostatic pressure and subjective sleepiness significantly increased during the night (rANOVA, P < 0.01) identically in both categories (rANOVA, NS). Resistant subjects sustained their reaction time independently of the increase in homeostatic pressure. The phenotypic determinants of vulnerability to extended wakefulness remain unknown.
虽然睡眠限制会降低表现，但并非所有人对睡眠不足的敏感性都相同。我们检验了这样一个假设，即表现可能与脑电图α-θ功率所定义的睡眠压力无关。20名健康受试者（10名易受影响者和10名耐受者）经历了25小时的睡眠剥夺。受试者必须每2小时（20:00 - 08:00）对自己的困倦程度进行评分（卡罗林斯卡困倦量表），并执行一项10分钟的心理运动警觉任务（PVT）。通过脑电图功率谱分析（α-θ频段6.0 - 9.0赫兹）测量睡眠压力。两组的初始表现、脑电图频谱功率和卡罗林斯卡困倦量表评分均无差异（方差分析，无显著差异）。易受影响的受试者的表现在夜间显著提高（重复测量方差分析，P < 0.01），而耐受受试者总体上保持了他们的表现。两组的体内平衡压力和主观困倦程度在夜间均显著增加（重复测量方差分析，P < 0.01），且两组之间无显著差异（重复测量方差分析）。耐受受试者的反应时间保持不变，与体内平衡压力的增加无关。长期清醒易感性的表型决定因素仍然未知。
