关于烯基芳基酮偶联模型反应的质谱研究。

Mass spectrometric studies on the coupling model reaction towards alkenyl-aryl ketones.

作者信息

Petz A, Pintér Z, Kollár L

机构信息

Department of Inorganic Chemistry, University of Pécs, H-7624 Pécs, Ifjúság u. 6., Hungary.

出版信息

J Biochem Biophys Methods. 2004 Oct 29;61(1-2):241-5. doi: 10.1016/j.jbbm.2004.02.005.

DOI:10.1016/j.jbbm.2004.02.005

PMID:15560940

Abstract

The palladium catalysed coupling reactions of 1-iodo-cyclohexene have been investigated with the aim of the synthesis of model compounds towards unsaturated aryl-alkenyl ketones of practical interest in carbonylative Suzuki reaction. In addition to the target compounds, the formation of 1-aryl-cyclohexene derivatives, 1,1'-bi(cyclohex-1-en-1-yl), 1,2-dicyclohex-1-en-1-yl-ethane-1,2-dione, dicyclohex-1-en-1-yl-ketone and 1-aryl-2-cyclohexenyl-cyclohexene derivatives, as well as their isomerization products, have been observed in parallel and consecutive reactions, respectively. The complex reaction mixtures have been analysed with GC-MS providing valuable information to the investigation of the homogeneous catalytic reaction.

摘要

为了合成在羰基化铃木反应中具有实际意义的不饱和芳基 - 烯基酮的模型化合物，对1 - 碘代环己烯的钯催化偶联反应进行了研究。除了目标化合物外，还分别在平行反应和连续反应中观察到了1 - 芳基环己烯衍生物、1,1'- 联（环己 - 1 - 烯 - 1 - 基）、1,2 - 二环己 - 1 - 烯 - 1 - 基乙烷 - 1,2 - 二酮、二环己 - 1 - 烯 - 1 - 基酮和1 - 芳基 - 2 - 环己烯基环己烯衍生物及其异构化产物的形成。利用气相色谱 - 质谱联用仪对复杂的反应混合物进行了分析，为均相催化反应的研究提供了有价值的信息。