Garcea Robert L, Gissmann Lutz
Section of Pediatric Hematology/Oncology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.
Curr Opin Biotechnol. 2004 Dec;15(6):513-7. doi: 10.1016/j.copbio.2004.10.002.
Virus-like particles (VLPs) structurally mimic the viral capsid and have therefore been extensively, and quite successfully, used as vaccine and viral serology reagents. The ability of VLPs to include nucleic acids and small molecules has also made them novel vessels for gene and drug delivery. The regular, repetitive surface of VLPs has been exploited as a template for nanoscale synthesis. Recent progress has been made in the development of several virus models.
病毒样颗粒（VLPs）在结构上模拟病毒衣壳，因此已被广泛且相当成功地用作疫苗和病毒血清学试剂。VLPs包含核酸和小分子的能力也使其成为基因和药物递送的新型载体。VLPs规则、重复的表面已被用作纳米级合成的模板。在几种病毒模型的开发方面已取得了最新进展。
