作为预防性或治疗性疫苗靶点的HIV非结构蛋白

Nonstructural HIV proteins as targets for prophylactic or therapeutic vaccines.

作者信息

Ferrantelli Flavia, Cafaro Aurelio, Ensoli Barbara

机构信息

AIDS Division, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

出版信息

Curr Opin Biotechnol. 2004 Dec;15(6):543-56. doi: 10.1016/j.copbio.2004.10.008.

DOI:10.1016/j.copbio.2004.10.008

PMID:15560981

Abstract

By the end of 2004, more than 20 HIV-1 vaccine candidates will have entered clinical testing in at least 30 trials worldwide. Almost half of these vaccines include nonstructural HIV-1 gene products. This represents an important innovation in the HIV vaccine field, because until 9 years ago not even preclinical testing in small animal models had been carried out with such immunogens. This review briefly discusses the experimental evidence that provides the rationale for the use of nonstructural HIV-1 gene products as vaccine antigens, and summarizes the current status and the future development of these novel vaccines.

摘要

到2004年底，全球至少30项试验中将会有20多种HIV-1候选疫苗进入临床试验阶段。这些疫苗中几乎有一半包含HIV-1非结构基因产物。这代表了HIV疫苗领域的一项重要创新，因为直到9年前，甚至都还没有在小动物模型中对这类免疫原进行过临床前测试。这篇综述简要讨论了为将HIV-1非结构基因产物用作疫苗抗原提供理论依据的实验证据，并总结了这些新型疫苗的现状和未来发展。