Haam Ji-Hee, Kim Young-Sang, Kim Moon Jong, Koo Hyung Suk, Kim Hyung Yuk, Kim Hye-Jung, Park Ki Hyun, Joo Nam-Seok, Park Kyung-Chae
Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Department of Family Medicine, Dongguk University Bundang Oriental Hospital, Seongnam, 13601, Republic of Korea.
J Bone Miner Metab. 2017 Nov;35(6):642-648. doi: 10.1007/s00774-016-0801-8. Epub 2016 Nov 21.
Results regarding the association between adipokine levels and bone mineral density (BMD) have been inconsistent; the effects of sex, menopause, and central obesity remain unknown. We evaluated the association between serum leptin, adiponectin, and high-molecular-weight (HMW) adiponectin levels and BMD according to menopause and central obesity status in Korean women. This cross-sectional study comprised 255 women undergoing examinations at the CHA Bundang Medical Center. Participants were divided according to menopause, and central obesity status. We measured serum adipokine levels and BMD using an enzyme-linked immunosorbent assay and dual-energy X-ray absorptiometry, respectively. After adjusting for age, body mass index, alkaline phosphatase levels and the Homeostasis Model Assessment index, leptin levels were negatively associated with non-vertebral BMD (total hip, β = -0.576, P = 0.006; femoral neck, β = -0.608, P = 0.007) in postmenopausal women without central obesity. Among women without central obesity, HMW adiponectin levels were positively associated with total hip BMD (β = 0.240, P = 0.010) in premenopausal women but negatively associated with BMD (lumbar, β = -0.436, P = 0.012; femoral neck, β = -0.468, P = 0.007) in postmenopausal women. Thus, the association between adipokine levels and BMD varies according to the menopause and central obesity status.
关于脂肪因子水平与骨密度（BMD）之间关联的研究结果并不一致；性别、绝经状态和中心性肥胖的影响仍不明确。我们根据绝经状态和中心性肥胖情况，评估了韩国女性血清瘦素、脂联素和高分子量（HMW）脂联素水平与骨密度之间的关联。这项横断面研究纳入了255名在CHA盆唐医疗中心接受检查的女性。参与者根据绝经状态和中心性肥胖情况进行分组。我们分别使用酶联免疫吸附测定法和双能X线吸收测定法测量血清脂肪因子水平和骨密度。在调整年龄、体重指数、碱性磷酸酶水平和稳态模型评估指数后，在无中心性肥胖的绝经后女性中，瘦素水平与非椎体骨密度呈负相关（全髋，β = -0.576，P = 0.006；股骨颈，β = -0.608，P = 0.007）。在无中心性肥胖的女性中，HMW脂联素水平在绝经前女性中与全髋骨密度呈正相关（β = 0.240，P = 0.010），但在绝经后女性中与骨密度呈负相关（腰椎，β = -0.436，P = 0.012；股骨颈，β = -0.468，P = 0.007）。因此，脂肪因子水平与骨密度之间的关联因绝经状态和中心性肥胖情况而异。
