Garcia Carlos A, Van Nostrand Douglas, Majd Massoud, Atkins Francis, Acio Elmo, Sheikh Anwer, Butler Calvin
Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010, USA.
Mol Imaging Biol. 2004 Nov-Dec;6(6):368-72. doi: 10.1016/j.mibio.2004.08.003.
Supraclavicular uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) on positron emission tomography (PET) scan is attributed to lymph node, muscle, or brown fat activity. Differentiation between physiological or pathological etiologies is necessary. Benzodiazepine premedication to reduce physiological uptake has been attempted with variable success. A relationship between brown-fat FDG uptake and cold temperature has also been established. To our knowledge, no case reports or studies have been published to demonstrate whether controlling the temperature can alter the physiological uptake in these regions.
Two teenage female patients with these patterns on PET scans performed with oral benzodiazepine administration underwent repeat imaging with temperature-controlled environment settings.
Resolution of supraclavicular FDG uptake with temperature control in two patients in whom benzodiazepine had no prior effect.
Although the exact mechanism remains unknown, we propose that the control of temperature reduces the metabolism of glucose by brown fat. Further studies are warranted to confirm the above observations, and, if confirmed, to determine the most efficient and effective use of temperature control to minimize supraclavicular and axillary FDG uptake.
正电子发射断层扫描（PET）中锁骨上2-脱氧-2-[¹⁸F]氟-D-葡萄糖（FDG）摄取归因于淋巴结、肌肉或棕色脂肪活性。区分生理或病理病因很有必要。曾尝试使用苯二氮䓬类药物进行预处理以减少生理性摄取，但效果不一。棕色脂肪FDG摄取与低温之间的关系也已确立。据我们所知，尚无病例报告或研究发表以证明控制温度是否能改变这些区域的生理性摄取。
两名口服苯二氮䓬类药物后PET扫描出现这些模式的青少年女性患者，在温度受控的环境设置下接受了重复成像。
两名患者在温度控制下锁骨上FDG摄取消失，而之前苯二氮䓬类药物对此无效。
尽管确切机制尚不清楚，但我们认为温度控制可降低棕色脂肪的葡萄糖代谢。有必要进行进一步研究以证实上述观察结果，若得到证实，则需确定控制温度的最有效方法以尽量减少锁骨上和腋窝FDG摄取。
