Misago Noriyuki, Satoh Toshimi, Narisawa Yutaka
Division of Dermatology, Department of Internal Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan.
Eur J Dermatol. 2004 Nov-Dec;14(6):383-7.
The object of this study was to elucidate the clinicopathological and immunohistochemical features of BCC with tubular structures. From the examination of 600 BCC specimens, we selected 10 cases of BCC with tubular structures. Immunohistochemistry was performed in these ten cases using antibodies against cytokeratins. All 10 BCCs (3 men and 7 women) were located on the face and scalp, particularly on the eyelid. The tubular structures could be classified histopathologically into ductal structures and glandular structures, which was supported by the results of the immunohistochemical study. The ductal structures represented various types and forms, small to medium-sized (the most common form), tiny, dilated, well-differentiated or acrosyringeal types. The glandular structures in one case suggested the features of apocrine secretion. BCC with tubular structures affected women more than men, and the favored location was the eyelid. The tubular structures in these BCCs differentiated toward either ductal or glandular structures, presumably of apocrine nature.
本研究的目的是阐明具有管状结构的基底细胞癌（BCC）的临床病理和免疫组织化学特征。通过对600例BCC标本的检查，我们选取了10例具有管状结构的BCC。对这10例病例使用细胞角蛋白抗体进行免疫组织化学检测。所有10例BCC（3例男性和7例女性）均位于面部和头皮，尤其是眼睑。管状结构在组织病理学上可分为导管结构和腺结构，免疫组织化学研究结果支持这一分类。导管结构呈现出各种类型和形态，小到中等大小（最常见的形态）、微小、扩张、高分化或顶泌汗腺样类型。1例中的腺结构提示大汗腺分泌的特征。具有管状结构的BCC女性多于男性，好发部位为眼睑。这些BCC中的管状结构向导管或腺结构分化，推测为大汗腺性质。
