Cheon Young Koog, Cho Young Deok, Baek Seung Hoon, Cha Sang Woo, Moon Jong Ho, Kim Yun Soo, Lee Jun Seong, Lee Moon Sung, Shim Chan Sup, Kim Boo Sung
Institute for Digestive Research and Digestive Disease Center, Soon Chun Hyang University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2004 Nov;44(5):280-7.
BACKGROUND/AIMS: Photodynamic therapy (PDT) has a promising effect on non-resectable hilar cholangiocarcinoma. The aim of this study was to compare overall survival of PDT plus biliary drainage versus biliary stent alone in advanced hilar cholangiocarcinoma.
Twenty patients who were treated with endoscopic biliary drainage alone (Group A) and 27 patients treated with PDT under percutaneous cholangioscopy and additional percutaneous biliary drainage (Group B) were analyzed retrospectively.
The mean bilirubin level declined effectively in both group after treatment. One-year survival was 28% in group A, 52% in group B (p<0.05). Median survival time was 288 days in group A, 558 days in group B (p=0.0143).
PDT under percutaneous cholangioscopy seems to be more effective in extending survival than biliary drainage alone in advanced hilar tumor. To investigate whether PDT can increase survival rates, further prospective, randomized study is needed.
背景/目的：光动力疗法（PDT）对不可切除的肝门部胆管癌有显著疗效。本研究旨在比较光动力疗法联合胆道引流与单纯胆道支架置入术治疗晚期肝门部胆管癌的总生存期。
回顾性分析20例单纯接受内镜下胆道引流的患者（A组）和27例接受经皮胆道镜下光动力疗法及经皮胆道引流的患者（B组）。
两组患者治疗后胆红素水平均有效下降。A组1年生存率为28%，B组为52%（p<0.05）。A组中位生存时间为288天，B组为558天（p=0.0143）。
对于晚期肝门部肿瘤，经皮胆道镜下光动力疗法在延长生存期方面似乎比单纯胆道引流更有效。为研究光动力疗法是否能提高生存率，需要进一步开展前瞻性随机研究。
