Ledesma-Montes Constantino, Garcés-Ortíz Maricela, Rosales-García Gilberto, Hernández-Guerrero Juan Carlos
Clinical and Experimental Oral Pathology Laboratory, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, México, D.F. México.
J Endod. 2004 Dec;30(12):855-9. doi: 10.1097/01.don.0000134207.67360.fc.
The role of mast cells (MCs) in periapical inflammatory lesions is not well understood. The objective of this work was to quantify MC numbers in human periapical lesions with the aim to clarify their role in the pathogenesis of these lesions. We analyzed the slides of 64 human periapical inflammatory lesions stained with pH 8.0 toluidine blue technique, quantified the number of MCs, and evaluated any correlation with age, gender, size, and location. The results of this study suggest that MCs were more numerous in females (p < 0.01); MC numbers were higher in biopsies from granulomas with proliferating epithelium and lower in biopsies from chronic apical abscesses; MC counts did not correlate with patients' age or size. MCs were observed more commonly in areas containing inflammatory infiltrate and degranulation was a frequent finding in these zones. Our results suggest that MCs play an active role in the pathogenesis of the periapical inflammatory lesions. The potential role of MCs related with the initiation, development, and persistence of the periapical inflammatory process are discussed.
肥大细胞（MCs）在根尖周炎性病变中的作用尚未完全明确。本研究的目的是对人类根尖周病变中的肥大细胞数量进行定量分析，以阐明其在这些病变发病机制中的作用。我们分析了64例经pH 8.0甲苯胺蓝染色技术染色的人类根尖周炎性病变切片，对肥大细胞数量进行了定量，并评估了其与年龄、性别、大小和位置的相关性。本研究结果表明，女性体内的肥大细胞数量更多（p < 0.01）；在伴有上皮增生的肉芽肿活检组织中，肥大细胞数量较多，而在慢性根尖脓肿活检组织中则较少；肥大细胞计数与患者年龄或病变大小无关。在含有炎性浸润的区域更常观察到肥大细胞，并且在这些区域脱颗粒现象很常见。我们的结果表明，肥大细胞在根尖周炎性病变的发病机制中发挥着积极作用。文中还讨论了肥大细胞在根尖周炎症过程的起始、发展和持续存在方面的潜在作用。
