Scrutton Nigel S
Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.
Nat Prod Rep. 2004 Dec;21(6):722-30. doi: 10.1039/b306788m. Epub 2004 Oct 20.
The mechanism of amine oxidation by flavoprotein enzymes is critically analysed through analysis of available experimental data. The review assesses available evidence for radical and polar mechanisms, drawing on data from model reactions, kinetic and spectroscopic approaches, structural and mutagenesis studies. The review focused on studies of mammalian monoamine oxidases and the bacterial enzymes trimethylamine dehydrogenase, monomeric sarcosine oxidase and dimethylglycine oxidase.
通过对现有实验数据的分析，对黄素蛋白酶氧化胺的机制进行了批判性分析。本综述利用模型反应、动力学和光谱学方法、结构和诱变研究的数据，评估了自由基和极性机制的现有证据。综述重点关注哺乳动物单胺氧化酶以及细菌酶三甲胺脱氢酶、单体肌氨酸氧化酶和二甲基甘氨酸氧化酶的研究。
