吡啶吖啶的生物活性。
Biological activities of pyridoacridines.
作者信息
Marshall Kathryn M, Barrows Louis R
机构信息
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.
出版信息
Nat Prod Rep. 2004 Dec;21(6):731-51. doi: 10.1039/b401662a. Epub 2004 Oct 29.
This review consolidates biological activity data reported for pyridoacridine 1 molecules in the literature from 1983-2003 into several tables with brief discussions of assays used and results obtained. This review summarizes recent progress in structure activity relationships for analogues of amphimedine 2 and ascididemin 3 classes of pyridoacridines and correlates reported molecular mechanisms of action with biological activities.
本综述将1983年至2003年文献中报道的吡啶吖啶1分子的生物活性数据整理成几个表格，并对所使用的测定方法和获得的结果进行了简要讨论。本综述总结了两性霉素2和海鞘素3类吡啶吖啶类似物的构效关系的最新进展，并将报道的作用分子机制与生物活性相关联。
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