Ibrahim Sabrin R M, Mohamed Gamal A
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah , Al Munawwarah 30078, Saudi Arabia (phone: +966-581-183034; fax:+966-484-75027).
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt, (phone: +20-88-2411330; fax: +20-88-2332776).
Chem Biodivers. 2016 Jan;13(1):37-47. doi: 10.1002/cbdv.201400434.
Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.
吡啶吖啶是一类严格意义上源自海洋的生物碱，构成了海洋生物碱中最大的化学家族之一。在过去几年中，天然吡啶吖啶及其类似物一直是合成研究的理想目标。由于它们具有显著的生物活性，如细胞毒性、抗菌、抗真菌、抗病毒、杀虫、抗HIV和抗寄生虫活性，因此一直是深入研究的对象。在本综述中，从海洋生物中分离出的95种吡啶吖啶生物碱的来源、生物合成、生物活性和结构归属进行了讨论。
