Tebruegge Marc, Curtis Nigel
Department of Paediatrics, The University of Melbourne, Parkville, Australia.
Clin Microbiol Rev. 2008 Jul;21(3):519-37. doi: 10.1128/CMR.00009-08.
Recurrent bacterial meningitis is a rare phenomenon and generally poses a considerable diagnostic challenge to the clinician. Ultimately, a structured approach and early diagnosis of any underlying pathology are crucial to prevent further episodes and improve the overall outcome for the affected individual. In this article, we are reviewing the existing literature on this topic over the last two decades, encompassing 363 cases of recurrent bacterial meningitis described in 144 publications. Of these cases, 214 (59%) were related to anatomical problems, 132 (36%) were related to immunodeficiencies, and 17 (5%) were related to parameningeal infections. The review includes a detailed discussion of the underlying pathologies and microbiological aspects as well as recommendations for appropriate diagnostic pathways for investigating this unusual entity.
复发性细菌性脑膜炎是一种罕见现象，通常给临床医生带来相当大的诊断挑战。最终，采用结构化方法并对任何潜在病理进行早期诊断对于预防进一步发作和改善受影响个体的总体预后至关重要。在本文中，我们回顾了过去二十年中关于该主题的现有文献，涵盖了144篇出版物中描述的363例复发性细菌性脑膜炎病例。在这些病例中，214例（59%）与解剖学问题有关，132例（36%）与免疫缺陷有关，17例（5%）与脑膜旁感染有关。该综述包括对潜在病理和微生物学方面的详细讨论，以及针对调查这一不寻常病症的适当诊断途径的建议。
