• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

寻常型天疱疮患者的人类白细胞抗原II类（DRB、DQA1和DQB1）等位基因及单倍型频率

HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris.

作者信息

Shams Sheida, Amirzargar Ali Akbar, Yousefi Maryam, Rezaei Nima, Solgi Ghasem, Khosravi Farideh, Ansaripour Bita, Moradi Batoul, Nikbin Behrouz

机构信息

Department of Dermatology, Razi Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Clin Immunol. 2009 Mar;29(2):175-9. doi: 10.1007/s10875-008-9244-x. Epub 2008 Sep 9.

DOI:10.1007/s10875-008-9244-x
PMID:18780165
Abstract

INTRODUCTION

Pemphigus vulgaris (PV), an autoimmune disease affecting the skin and mucous membranes, is associated with some human leukocyte antigen (HLA) class II alleles and haplotypes.

MATERIALS AND METHODS

In order to evaluate the association of HLA-DR and DQ alleles and haplotypes in Iranian non-Jewish patients with PV, 52 patients with PV and 180 normal subjects as control group were investigated in this study.

RESULTS AND DISCUSSION

HLA-DRB104, -DRB11401, -DRB4, -DQA10104, -DQA103011, -DQB10302, and -DQB10502 alleles have been significantly increased in our patients group. Moreover, the haplotypes HLA-DRB104/-DQA103011/-DQB10302 and HLA-DRB11401/-DQA10104/-DQB10502 increased significantly in our patients. In contrast, the following alleles decreased significantly in our patients: HLA-DRB115, -DRB10301, -DRB107, -DRB111, -DRB5, -DQA10101, -DQA10103, -DQA1201, -DQA105, -DQB10201, -DQB10301, -DQB106011, and -DQB10602. In addition, HLA-DRB115/-DQA10103/-DQB106011, HLA-DRB10301/-DQA105011/-DQB10201, HLA-DRB107/-DQA10201/-DQB10201, and HLA-DRB111/-DQA105/-DQB103011 decreased significantly in our patients. Genetic factors are involved in the occurrence of PV; HLA-DRB104 and -DRB11401 alleles and the related haplotypes are suggestive to be two major PV susceptibility factors in our population study.

摘要

引言

寻常型天疱疮（PV）是一种影响皮肤和黏膜的自身免疫性疾病，与一些人类白细胞抗原（HLA）II类等位基因和单倍型相关。

材料与方法

为了评估伊朗非犹太裔PV患者中HLA-DR和DQ等位基因及单倍型的关联性，本研究调查了52例PV患者和180名正常受试者作为对照组。

结果与讨论

在我们的患者组中，HLA-DRB104、-DRB11401、-DRB4、-DQA10104、-DQA103011、-DQB10302和-DQB10502等位基因显著增加。此外，单倍型HLA-DRB104/-DQA103011/-DQB10302和HLA-DRB11401/-DQA10104/-DQB10502在我们的患者中显著增加。相比之下，以下等位基因在我们的患者中显著减少：HLA-DRB115、-DRB10301、-DRB107、-DRB111、-DRB5、-DQA10101、-DQA10103、-DQA1201、-DQA105、-DQB10201、-DQB10301、-DQB106011和-DQB10602。此外，HLA-DRB115/-DQA10103/-DQB106011、HLA-DRB10301/-DQA105011/-DQB10201、HLA-DRB107/-DQA10201/-DQB10201和HLA-DRB111/-DQA105/-DQB103011在我们的患者中显著减少。遗传因素参与了PV的发生；HLA-DRB104和-DRB11401等位基因以及相关单倍型在我们的人群研究中提示为两个主要的PV易感因素。

相似文献

1
HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris.寻常型天疱疮患者的人类白细胞抗原II类（DRB、DQA1和DQB1）等位基因及单倍型频率
J Clin Immunol. 2009 Mar;29(2):175-9. doi: 10.1007/s10875-008-9244-x. Epub 2008 Sep 9.
2
MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India.来自印度的寻常型天疱疮患者的MHC II类等位基因和单倍型
Tissue Antigens. 1996 Dec;48(6):668-72. doi: 10.1111/j.1399-0039.1996.tb02690.x.
3
Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population.日本人群中自身免疫性多腺体综合征III型患者人类白细胞抗原DRB1、DQA1和DQB1的易感等位基因及单倍型
Horm Res. 2005;64(5):253-60. doi: 10.1159/000089293. Epub 2005 Oct 27.
4
HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method.采用聚合酶链反应-限制性片段长度多态性方法对日本寻常型天疱疮患者进行HLA-DQA1、-DQB1和-DRB1基因分型。
Tissue Antigens. 1994 Oct;44(4):248-51. doi: 10.1111/j.1399-0039.1994.tb02390.x.
5
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region.寻常型天疱疮和落叶型天疱疮患者在巴西东南部流行地区的 HLA Ⅰ类和Ⅱ类别差异相关。
J Autoimmun. 2016 Aug;72:19-24. doi: 10.1016/j.jaut.2016.04.007. Epub 2016 May 10.
6
Human leukocyte antigen class II allele frequencies and haplotype association in Iranian normal population.伊朗正常人群中人类白细胞抗原II类等位基因频率及单倍型关联
Hum Immunol. 2001 Nov;62(11):1234-8. doi: 10.1016/s0198-8859(01)00320-2.
7
Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病DR2阳性患者的抗体标志物、DRB1、DRB5、DQA1和DQB1基因分析及DR2分子建模
Tissue Antigens. 1994 Aug;44(2):110-9. doi: 10.1111/j.1399-0039.1994.tb02366.x.
8
HLA class II allele associations in Korean patients with pemphigus.韩国天疱疮患者的HLA II类等位基因关联
Dermatology. 1998;197(4):349-52. doi: 10.1159/000018030.
9
Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients.寻常型天疱疮自身抗体反应与巴基斯坦患者的HLA - DQB1*0503相关。
Hum Immunol. 1997 Oct;57(2):110-9. doi: 10.1016/s0198-8859(97)00203-6.
10
Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations.约旦人HLA等位基因频率和单倍型的分子分析及其与其他相关人群的比较。
Hum Immunol. 2001 Sep;62(9):901-9. doi: 10.1016/s0198-8859(01)00289-0.

引用本文的文献

1
Cholesterol-saturated fat index and severity of pemphigus vulgaris: a cross-sectional study.胆固醇-饱和脂肪指数与寻常型天疱疮的严重程度：一项横断面研究。
Arch Dermatol Res. 2024 Sep 6;316(8):609. doi: 10.1007/s00403-024-03242-3.
2
Association of alternative healthy eating index and severity of pemphigus vulgaris: A cross-sectional study.替代健康饮食指数与寻常型天疱疮严重程度的相关性：一项横断面研究。
PLoS One. 2023 Dec 11;18(12):e0295026. doi: 10.1371/journal.pone.0295026. eCollection 2023.
3
HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies.

本文引用的文献

1
Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China.中国东北地区汉族人群寻常型天疱疮与人类白细胞抗原的相关性
Chin Med Sci J. 2005 Sep;20(3):166-70.
2
Pemphigus: analysis of 1209 cases.天疱疮：1209例病例分析。
Int J Dermatol. 2005 Jun;44(6):470-6. doi: 10.1111/j.1365-4632.2004.02501.x.
3
Number II. Pemphigus vulgaris.第二。寻常型天疱疮。
HLA Ⅱ类抗原在克罗地亚寻常型天疱疮患者中的表达及其与抗桥粒芯糖蛋白抗体的相关性。
Front Immunol. 2023 Jul 17;14:1200992. doi: 10.3389/fimmu.2023.1200992. eCollection 2023.
4
Association of specific HLA alleles and haplotypes with pemphigus vulgaris in the Bulgarian population.保加利亚人群中寻常型天疱疮与特定 HLA 等位基因和单倍型的关联。
Front Immunol. 2022 Aug 2;13:901386. doi: 10.3389/fimmu.2022.901386. eCollection 2022.
5
HLA-DRB1 and DQB1 genetic susceptibility to pemphigus vulgaris and pemphigus foliaceus in Vietnamese patients.越南患者中HLA - DRB1和DQB1基因对寻常型天疱疮和落叶型天疱疮的遗传易感性
Dermatol Reports. 2021 Aug 5;14(2):9286. doi: 10.4081/dr.2021.9286. eCollection 2022 Jun 16.
6
A systematic review and meta-analysis of HLA class II associations in patients with IgG4 autoimmunity.IgG4 自身免疫患者 HLA-II 类相关性的系统评价和荟萃分析。
Sci Rep. 2022 Jun 2;12(1):9229. doi: 10.1038/s41598-022-13042-2.
7
The Immunogenetics of Autoimmune Blistering Diseases.自身免疫性水疱病的免疫遗传学。
Adv Exp Med Biol. 2022;1367:173-212. doi: 10.1007/978-3-030-92616-8_8.
8
Autoimmune Pemphigus: Latest Advances and Emerging Therapies.自身免疫性天疱疮：最新进展与新兴疗法
Front Mol Biosci. 2022 Feb 4;8:808536. doi: 10.3389/fmolb.2021.808536. eCollection 2021.
9
Autoantibody-Specific Signalling in Pemphigus.天疱疮中的自身抗体特异性信号传导
Front Med (Lausanne). 2021 Aug 9;8:701809. doi: 10.3389/fmed.2021.701809. eCollection 2021.
10
Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein.寻常型天疱疮病理生理学中的演变机制：一篇强调桥粒芯糖蛋白3在调节p53和Yes相关蛋白中作用的综述
Life (Basel). 2021 Jun 26;11(7):621. doi: 10.3390/life11070621.
Oral Dis. 2005 May;11(3):119-30. doi: 10.1111/j.1601-0825.2005.01139.x.
4
Genetic factors in pemphigus.天疱疮的遗传因素
J Autoimmun. 2005 Jun;24(4):319-28. doi: 10.1016/j.jaut.2005.03.006.
5
The immunogenetics of pemphigus vulgaris.寻常型天疱疮的免疫遗传学
Autoimmun Rev. 2005 Jan;4(1):16-20. doi: 10.1016/j.autrev.2004.05.002.
6
The association of HLA-DRB, DQA1, DQB1 alleles and haplotype frequency in Iranian patients with pulmonary tuberculosis.伊朗肺结核患者中HLA-DRB、DQA1、DQB1等位基因及单倍型频率的关联
Int J Tuberc Lung Dis. 2004 Aug;8(8):1017-21.
7
Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers.寻常型天疱疮在犹太人和西班牙人中的共同祖先起源：一项使用微卫星标记的研究
Tissue Antigens. 2004 Apr;63(4):326-34. doi: 10.1111/j.0001-2815.2004.00191.x.
8
T-cellular autoimmunity against desmogleins in pemphigus, an autoantibody-mediated bullous disorder of the skin.天疱疮是一种自身抗体介导的皮肤大疱性疾病，存在针对桥粒芯糖蛋白的T细胞自身免疫反应。
Autoimmun Rev. 2003 Sep;2(5):278-83. doi: 10.1016/s1568-9972(03)00035-1.
9
Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers.犹太患者中的寻常型天疱疮与HLA - A区域基因相关：通过微卫星标记进行定位
Hum Immunol. 2003 Aug;64(8):771-9. doi: 10.1016/s0198-8859(03)00092-2.
10
Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles.寻常型天疱疮（PV）患者及PV相关HLA II类等位基因健康携带者中，针对桥粒芯糖蛋白3的自身反应性Th1和Th2细胞反应的二分法。
J Immunol. 2003 Jan 1;170(1):635-42. doi: 10.4049/jimmunol.170.1.635.