[中国人喉肿瘤与人类乳头瘤病毒感染关系的Meta分析]

[Meta analysis of relationship between laryngeal tumor of chinese and human papillomavirus infection].

作者信息

Chai Li-Ping, Su Zhen-Zhong, Lei Wen-Bin, Liang Wei-Ying

机构信息

Hospital of Otorhinolaryngology, The First Affiliated Hospital, Research Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R.China.

出版信息

Ai Zheng. 2004 Nov;23(11 Suppl):1400-4.

PMID:15566644

Abstract

BACKGROUND & OBJECTIVE: Researches showed that the infection of human papillomavirus (HPV) was closely related to laryngeal tumor, but those results existed great differences because of different research methods. In this study Fisher's and Meta analysis were used to synthetically evaluate relationship between laryngeal benign and malignant tumors of Chinese and infection of different types of HPV.

METHODS

A total of 123 references about relationship between laryngeal benign and malignant tumors of Chinese and infection of different types of HPV were collected from CBMdisc (Chinese Biomedical Literature Analysis and Retrieval System for Compact Disc). There were 11 references accorded with research criteria which were case-control study, and had detected HPV16 or HPV6/11 by polymerase chain reaction (PCR). Fisher and Meta analysis were used to quantitatively and qualitatively analyze these references synthetically.

RESULTS

Mean detection rates of HPV16 in normal laryngeal tissue, laryngeal carcinoma (LC), laryngeal papilloma(LPa), laryngeal polyp (LPo) from all references were 10.8%,35.2%,27.5%,5.0%, respectively; and those of HPV6/11 were 8.7%, 18.6%, 61.6%, 21.9%, respectively. The infection of HPV16 in LC were significantly higher than those in LPa, and LPo (P< 0.005); the combined odds ratio (ORc) for HPV16 infection in LC was 2.8 (1.7-4.7) times that in LPa, and 12.7 (4.2-38.8) times that in LPo; mean positive rate of HPV16 in LC was 22.0% (12.2%-31.8%) higher than that in LPa, and 39.0% (19.4%-58.6%) higher than that in Lpo. The infection of HPV6/11 in LPa was significantly higher than that in LC (P< 0.005); OR(c) for HPV16 infection in LPa was 16.4 (5.6-48.1) times that LC; mean positive rate of HPV16 in LPa was 56.0% (34.4%-75.6%) higher than that in LC. There was no significant difference of HPV6/11 infection between LC and LPo (P >0.05).

CONCLUSION

The infection of HPV16 may enhance risk of development of laryngeal carcinoma; and the infection of HPV6/11 may enhance risk of development of laryngeal papilloma.

摘要

背景与目的

研究表明，人乳头瘤病毒（HPV）感染与喉肿瘤密切相关，但因研究方法不同，结果存在较大差异。本研究采用Fisher检验和Meta分析综合评价中国人喉良、恶性肿瘤与不同类型HPV感染的关系。

方法

从中国生物医学文献光盘数据库（CBMdisc）收集123篇关于中国人喉良、恶性肿瘤与不同类型HPV感染关系的文献。其中11篇符合研究标准，均为病例对照研究，且采用聚合酶链反应（PCR）检测HPV16或HPV6/11。运用Fisher检验和Meta分析对这些文献进行定量和定性综合分析。

结果

所有文献中，正常喉组织、喉癌（LC）、喉乳头状瘤（LPa）、喉息肉（LPo）中HPV16的平均检出率分别为10.8%、35.2%、27.5%、5.0%；HPV6/11的平均检出率分别为8.7%、18.6%、61.6%、21.9%。喉癌中HPV16感染率显著高于喉乳头状瘤和喉息肉（P<0.005）；喉癌中HPV16感染的合并比值比（ORc）是喉乳头状瘤的2.8（1.7 - 4.7）倍，是喉息肉的12.7（4.2 - 38.8）倍；喉癌中HPV16的平均阳性率比喉乳头状瘤高22.0%（12.2% - 31.8%），比喉息肉高39.0%（19.4% - 58.6%）。喉乳头状瘤中HPV6/11感染率显著高于喉癌（P<0.005）；喉乳头状瘤中HPV6/11感染的ORc是喉癌的16.4（5.6 - 48.1）倍；喉乳头状瘤中HPV6/11的平均阳性率比喉癌高56.0%（34.4% - 75.6%）。喉癌与喉息肉中HPV6/11感染率差异无统计学意义（P>0.05）。