Blum Arnon, Schneider David J, Sobel Burton E, Dauerman Harold L
Department of Internal Medicine A, Poria Medical Center, Lower Galilee, Israel.
Am J Cardiol. 2004 Dec 1;94(11):1420-3. doi: 10.1016/j.amjcard.2004.07.146.
We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 +/- 20.2 vs 5.6 +/- 13.0 microg/ml, p = 0.04) and 24 hours after stenting (18.8 +/- 20.8 vs 11.8 +/- 20.0 microg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.
我们研究了30例连续接受冠状动脉支架置入术的患者，观察术后内皮功能障碍以及术前和术后细胞因子水平。与全身内皮功能无严重异常的患者相比，血流介导的依赖性扩张严重受损（而非血流介导的非依赖性扩张严重受损）的患者在经皮冠状动脉介入治疗前（12.9±20.2对5.6±13.0微克/毫升，p = 0.04）和支架置入后24小时（18.8±20.8对11.8±20.0微克/毫升，p = 0.05）的C反应蛋白浓度更高。因此，内皮依赖性扩张异常与全身炎症状态相关，而内皮非依赖性扩张异常与患者的炎症状态无关。
