Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G
Rheumatology Unit, United Medical School, Guy's Hospital, London, UK.
J Rheumatol. 1992 Jan;19(1):22-5.
Disease activity in rheumatoid arthritis (RA) is frequently associated with a marked acute phase response, thrombocytosis, hypergammaglobulinemia and the presence of rheumatoid factors (RF). Interleukin 6 (IL-6) is a cytokine that stimulates hepatocytes to produce acute phase reactants and B lymphocytes to produce immunoglobulin. We measured serum IL-6 in patients with active RA during induction of intramuscular gold therapy. Levels of IL-6 correlated strongly with the erythrocyte sedimentation rate and RF titers and to a lesser degree with platelet counts. It may, therefore, be responsible for many of the systemic manifestations of RA and its measurement in the serum may be a convenient and reproducible variable for the assessment of disease activity in this very common disease.
类风湿关节炎（RA）的疾病活动通常与明显的急性期反应、血小板增多、高球蛋白血症以及类风湿因子（RF）的存在有关。白细胞介素6（IL-6）是一种细胞因子，可刺激肝细胞产生急性期反应物，并刺激B淋巴细胞产生免疫球蛋白。我们在肌肉注射金制剂治疗诱导期对活动期RA患者的血清IL-6进行了测量。IL-6水平与红细胞沉降率和RF滴度密切相关，与血小板计数的相关性较小。因此，它可能是RA许多全身表现的原因，血清中IL-6的测量可能是评估这种常见疾病疾病活动的一个方便且可重复的指标。
