Dezelić G, Dürrigl T, Dezelić N, Zergollern V, Jurak H, Vitaus M, Androić S
Z Rheumatol. 1978 Mar-Apr;37(3-4):112-22.
The photometric latex test (PLT) for the detection of rheumatoid factors has been clinically evaluated. PLT titers have been closely studied in relation to clinical and laboratory parameters by means of parametric and nonparametric statistical methods. An analysis of the sensitized sheep cell test (SSC) titers has also been undertaken. The subjects comprised 377 patients with rheumatoid arthritis (RA) and 120 controls. The medical data recorded included sex, age, diagnosis, anatomical stage, functional class, duration and course of the disease, presence of the American Rheumatism Association (ARA) criteria, blood sedimentation rate, red and white blood counts, haemoglobin concentration, total protein content, serum protein levels, and SSC and PLT titers. A multivariate stepwise regression analysis with eight normally distributed variables was made. In accordance with previous findings, a significant correlation was shown to exist between the serum protein levels and the development of the RA when the anatomical stage, functional class and course of the disease were used as parameters of disease activity. In the RA patients there was also correlation between the serologic titers and the serum protein levels, and the anatomical stage, functional class and course of the disease, and the sedimentation rate, thus showing that titers can also serve as a measure of the inflammatory process. There was a significant correlation between the number of ARA criteria and the titers in the RA patients but not in the controls. The course of the disease correlated with the serum titers and other inflammatory parameters, a finding showing that the course of the disease is an important diagnostic parameter with possible prognostic value. Correlation was also demonstrated between the white blood count and the titers. It is concluded that the sedimentation rate, albumin and gamma-globulin levels, and PLT titer are the best parameters of disease activity. The titer values are not only of diagnostic importance but have prognostic value as regards the severity of the disease.
用于检测类风湿因子的光度乳胶试验（PLT）已进行临床评估。通过参数和非参数统计方法，对PLT滴度与临床和实验室参数的关系进行了深入研究。同时也对致敏绵羊细胞试验（SSC）滴度进行了分析。研究对象包括377例类风湿关节炎（RA）患者和120名对照者。记录的医学数据包括性别、年龄、诊断、解剖分期、功能分级、疾病持续时间和病程、美国风湿病协会（ARA）标准的存在情况、血沉、红细胞和白细胞计数、血红蛋白浓度、总蛋白含量、血清蛋白水平以及SSC和PLT滴度。对八个正态分布变量进行了多元逐步回归分析。与先前的研究结果一致，当将解剖分期、功能分级和疾病病程用作疾病活动参数时，血清蛋白水平与RA的发生之间存在显著相关性。在RA患者中，血清滴度与血清蛋白水平、解剖分期、功能分级和疾病病程以及血沉之间也存在相关性，这表明滴度也可作为炎症过程的一种衡量指标。RA患者中ARA标准的数量与滴度之间存在显著相关性，而对照者中则不存在。疾病病程与血清滴度和其他炎症参数相关，这一发现表明疾病病程是一个重要的诊断参数，可能具有预后价值。白细胞计数与滴度之间也显示出相关性。结论是，血沉、白蛋白和γ-球蛋白水平以及PLT滴度是疾病活动的最佳参数。滴度值不仅具有诊断重要性，而且对于疾病的严重程度具有预后价值。
