Gao Xiaoping, Zhang Guolin, Zhou Min, Luo Dixiang, Li Bogang
Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu 610041, China.
Fitoterapia. 2004 Dec;75(7-8):639-44. doi: 10.1016/j.fitote.2004.06.008.
A dose-dependent and significant (P<0.01) antiproliferative effect of Goldfussia psilostachys ethanolic extract was observed on K562 cells. The IC(50) is ca. 0.5 microg/ml. The extract markedly increases the proportion of cell in G2/M phases and decreases the population of cells in G0/G1 phases. Moreover, the antimitotic effect is correlated with polymerization of microtubule assembly. These results indicate that G. psilostachys ethanolic extract inhibits the proliferation of K562 cells and disrupts the normal dynamic of microtubules during mitosis.
观察到金足草乙醇提取物对K562细胞具有剂量依赖性且显著的（P<0.01）抗增殖作用。半数抑制浓度（IC50）约为0.5微克/毫升。该提取物显著增加了处于G2/M期的细胞比例，并减少了处于G0/G1期的细胞数量。此外，抗有丝分裂作用与微管组装的聚合相关。这些结果表明，金足草乙醇提取物抑制K562细胞的增殖，并在有丝分裂过程中破坏微管的正常动态。
