Bornhöft Martin, Thommes Markus, Kleinebudde Peter
Institute of Pharmaceutics and Biopharmaceutics, Martin-Luther-University, Halle-Wittenberg, Germany.
Eur J Pharm Biopharm. 2005 Jan;59(1):127-31. doi: 10.1016/j.ejpb.2004.05.007.
The current study pursues the suitability of different types of carrageenan as a novel extrusion aid. The aim was to find out a suitable substitution to the commonly used microcrystalline cellulose (MCC). The types of kappa-carrageenan were found to be the most appropriate material and the required fraction to produce acceptable pellets in the formulation was determined. The investigation showed that 5% of kappa-carageenan was necessary to produce pellets without MCC. Similar formulations produced with MCC or kappa-carrageenan were compared with respect to size and shape of the pellets. kappa-Carrageenan required higher water content for the formation of pellets, but the formulation was more robust as the optimal range of water content was much broader. Hence, kappa-Carrageenan seems to be a suitable and promising extrusion aid. The study showed that the substitution of MCC by kappa-carrageenan in formulations is possible and the produced pellets were of high quality.
本研究探讨了不同类型卡拉胶作为新型挤出助剂的适用性。目的是找出一种合适的材料来替代常用的微晶纤维素（MCC）。结果发现κ-卡拉胶是最合适的材料，并确定了在配方中生产出可接受颗粒所需的用量。研究表明，在没有MCC的情况下，需要5%的κ-卡拉胶才能生产出颗粒。比较了用MCC或κ-卡拉胶生产的类似配方颗粒的大小和形状。κ-卡拉胶形成颗粒需要更高的含水量，但由于含水量的最佳范围更宽，该配方更稳定。因此，κ-卡拉胶似乎是一种合适且有前景的挤出助剂。研究表明，在配方中用κ-卡拉胶替代MCC是可行的，并且生产出的颗粒质量很高。
