Lee K W, Wood N B, Xu X Y
Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Med Eng Phys. 2004 Dec;26(10):823-40. doi: 10.1016/j.medengphy.2004.08.013.
Ultrasound scans were acquired from a common carotid artery in a patient with an early atherosclerotic plaque forming a mild asymmetrical stenosis. The 3D vascular geometry of the diseased arterial segment was reconstructed from a series of 2D cross-sectional images, and computational meshes for the flow and wall domains were developed. Numerical flow simulations incorporating coupled fluid-solid interaction were implemented using flow and pressure waveforms measured in vivo. The effects of wall distensibility were investigated by comparing the predictions obtained with different wall compliance, one with 'natural' compliance and another with a stiffer wall. Limited flow separation was predicted in the post-stenotic zone. The non-uniform thickness of the diseased wall restricted the wall motion locally and re-distributed the stress, giving raised concentrations at the plaque shoulders.
对一名患有早期动脉粥样硬化斑块并形成轻度不对称狭窄的患者的颈总动脉进行了超声扫描。从一系列二维横截面图像重建了病变动脉段的三维血管几何形状，并开发了用于流动和壁域的计算网格。使用体内测量的流动和压力波形进行了包含流固耦合相互作用的数值流动模拟。通过比较不同壁顺应性（一种为“自然”顺应性，另一种为更硬的壁）获得的预测结果，研究了壁扩张性的影响。预测在狭窄后区域存在有限的流动分离。病变壁的厚度不均匀局部限制了壁的运动并重新分布了应力，在斑块肩部产生了升高的浓度。
