Xia Chang-Suo, Han Ying-Qiu, Yang Xuan-Ying, Hong Guang-Xiang
Department of Orthopaedics, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
Hepatobiliary Pancreat Dis Int. 2004 Nov;3(4):595-8.
Spinal cord injury (SCI) is found to be related to increased prevalence of gallstones and acute acalculous cholecystitis. In this study we assessed the prevalence of cholelithiasis in male patients with SCI and the correlation of cholelithiasis with age and weight of patients, level of injury, as well as severity and duration of SCI.
One hundred male SCI patients (58 patients rated ASIA A or B and 42 rated ASIA C or D) aged more than 20 years (average 46.5 years) suffered from a spinal cord injury for more than one year. One hundred male volunteers served as controls without SCI and biliary diseases(age range 20-68 years; average 42.6 years). The two groups were subjected to ultrasonography of the gallbladder and biliary tract.
The prevalence of cholelithiasis in the group of SCI patients and the control group was 26% and 10% respectively. Significant differences in the prevalence of cholelithiasis were found between the normal controls and SCI patients and between high and low-level injury (P<0.01). But the differences were not statistically significant when correlating the presence of cholelithiasis with the age and weight of the patients, the duration of SCI, and the severity of spinal lesion(P>0.05).
SCI represents a major risk factor for the development of cholelithiasis,especially in patients with high-level injury. Cholelithiasis in SCI patients is not related to their age and weight, the severity of spinal lesion, and the duration of spinal cord injury.
脊髓损伤（SCI）与胆结石和急性非结石性胆囊炎的患病率增加有关。在本研究中，我们评估了男性脊髓损伤患者胆结石的患病率，以及胆结石与患者年龄、体重、损伤水平、脊髓损伤的严重程度和持续时间之间的相关性。
100例年龄超过20岁（平均46.5岁）、脊髓损伤超过1年的男性脊髓损伤患者（58例ASIA A或B级，42例ASIA C或D级）。100名男性志愿者作为对照，无脊髓损伤和胆道疾病（年龄范围20 - 68岁；平均42.6岁）。两组均接受胆囊和胆道超声检查。
脊髓损伤患者组和对照组胆结石的患病率分别为26%和10%。正常对照组与脊髓损伤患者之间以及高、低水平损伤之间胆结石患病率存在显著差异（P<0.01）。但胆结石的存在与患者年龄、体重、脊髓损伤持续时间以及脊髓损伤严重程度之间的差异无统计学意义（P>0.05）。
脊髓损伤是胆结石形成的主要危险因素，尤其是在高位损伤患者中。脊髓损伤患者的胆结石与他们的年龄、体重、脊髓损伤严重程度以及脊髓损伤持续时间无关。
