Gaulard Philippe, Brousse Nicole
Département de Pathologie et Inserm U617, Hôpital Henri Mondor, 94010 Créteil Cedex, France.
Ann Pathol. 2004 Sep;24(4):330-48. doi: 10.1016/s0242-6498(04)93981-8.
Advances in the biology of Hodgkin's lymphoma have lead to the distinction between two entities, "classical" Hodgkin's lymphoma and nodular lymphocyte predominance Hodgkin's lymphoma, previously called nodular paragranuloma, which share distinct clinical aspects. The definition of diagnostic criteria has also been helpful to separate Hodgkin's lymphoma from other lymphomas which can mimick Hodgkin's disease such as anaplastic large cell lymphomas, T-cell/histiocyte rich diffuse large B-cell lymphoma, and some peripheral T-cell lymphomas, mainly angioimmunoblastic-type. Reed-Sternberg cell, the neoplastic cell of "classical" Hodgkin's lymphoma, still retains some secrets. Despite some controversies, there is more and more evidence for a lymphoid B cell origin. The involvement of Epstein-Barr virus, cytokines and/or oncogenes expression in the pathogeny can be suggested, although the precise mechanisms leading to transformation and/or accounting for tumour progression are still elusive. Recently, the roles of the pathway implicating the activation of NFkappaB as well as the autocrine secretion of interleukin-13 have been demonstrated.
霍奇金淋巴瘤生物学领域的进展已导致区分出两种实体，即“经典型”霍奇金淋巴瘤和结节性淋巴细胞为主型霍奇金淋巴瘤（以前称为结节性副肉芽肿），它们具有不同的临床特征。诊断标准的定义也有助于将霍奇金淋巴瘤与其他可能模仿霍奇金病的淋巴瘤区分开来，如间变性大细胞淋巴瘤、富于T细胞/组织细胞的弥漫性大B细胞淋巴瘤以及一些外周T细胞淋巴瘤，主要是血管免疫母细胞型。里德-斯腾伯格细胞是“经典型”霍奇金淋巴瘤的肿瘤细胞，仍隐藏着一些秘密。尽管存在一些争议，但越来越多的证据支持其起源于B淋巴细胞。虽然导致转化和/或肿瘤进展的确切机制仍不清楚，但可以推测爱泼斯坦-巴尔病毒、细胞因子和/或癌基因表达在发病机制中的作用。最近，涉及核因子κB激活以及白细胞介素-13自分泌的信号通路的作用已得到证实。
