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评估由苯海索和HI-6组成的药物组合对梭曼中毒大鼠的治疗和抗惊厥疗效。

Assessment of the therapeutic and anticonvulsive efficacy of a drug combination consisting of trihexyphenidyle and HI-6 in soman-poisoned rats.

作者信息

Kassa Jirí, Samnaliev Ivan

机构信息

Purkyne Military Medical Academy in Hradec Králové, Czech Republic: Department of Toxicology.

出版信息

Acta Medica (Hradec Kralove). 2004;47(3):171-5.

PMID:15568734
Abstract
  1. The influence of two anticholinergic drugs (atropine, trihexyphenidyle) on the effectiveness of antidotal treatment to eliminate soman-induced lethal effects and convulsions was studied in rats. 2. The oxime HI-6 when combined with centrally acting anticholinergic drug trihexyphenidyle seems to be more efficacious in the elimination of acute toxic effects of soman than its combination with atropine. 3. The findings support the hypothesis that the choice of the anticholinergic drug is important for the effectiveness of antidotal mixture in the case of antidotal treatment of soman-induced acute poisoning.
摘要
  1. 研究了两种抗胆碱能药物（阿托品、苯海索）对消除大鼠中梭曼致死效应和惊厥的解毒治疗效果的影响。2. 肟类药物HI-6与中枢作用抗胆碱能药物苯海索联合使用时，在消除梭曼急性毒性作用方面似乎比与阿托品联合使用更有效。3. 这些发现支持以下假设：在对梭曼引起的急性中毒进行解毒治疗时，抗胆碱能药物的选择对解毒混合物的效果很重要。

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