Cheng Yongxian, Schneider Bernd, Riese Ulrike, Schubert Barbara, Li Zengzhi, Hamburger Matthias
Institute of Pharmacy, Friedrich-Schiller-University Jena, Semmelweisstrasse 10, D-07743 Jena, Germany.
J Nat Prod. 2004 Nov;67(11):1854-8. doi: 10.1021/np049761w.
Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new metabolite derived from an early step of pyridone alkaloid biosynthesis. The structures were determined by spectroscopic means, in particular by extensive NMR experiments. Compounds 1 and 3 induced neurite outgrowth in the PC-12 cell line at concentrations of 50 microM, while compound 2 was inactive. No cytotoxicity was observed for compounds 1-3 in PC-12 cells when tested at 50 microM concentration in the MTT assay.
从昆虫病原真菌菌株粉拟青霉RCEF 0101的菌丝体提取物中分离出两种新的黄色色素，即粉质菌素A（1）和B（2），以及一种新的代谢产物粉质菌素C（3），它是吡啶酮生物碱生物合成早期步骤的产物。通过光谱手段，特别是广泛的核磁共振实验确定了其结构。化合物1和3在浓度为50微摩尔时可诱导PC-12细胞系中的神经突生长，而化合物2无活性。在MTT试验中，当以50微摩尔浓度测试时，化合物1 - 3在PC-12细胞中未观察到细胞毒性。
