Nassif Deborah S, Piskun Nadya V, Gramatikov Boris I, Guyton David L, Hunter David G
Harvard Medical School, Children's Hospital Boston, Department of Ophthalmology, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
J Biomed Opt. 2004 Nov-Dec;9(6):1369-74. doi: 10.1117/1.1805561.
Amblyopia is a form of visual impairment caused by ocular misalignment (strabismus) or defocus in an otherwise healthy eye. If detected early, the condition can be fully treated, yet over half of all children with amblyopia under age 5 escape detection. We developed a Pediatric Vision Screener (PVS) to detect amblyopia risk factors. This instrument produces a binocularity score to indicate alignment and a focus score to indicate focus. The purpose of this study is to assess the performance of the PVS by testing adults who were fully cooperative for testing. The study group includes 40 subjects (20 controls, 20 patients) aged 22 to 79 years. 12 patients had constant strabismus (8 to 50Delta), and eight had variable strabismus (12 to 55Delta). All controls had binocularity scores >50%. Binocularity was <50% in 11/12 patients. The patient with binocularity >50% had a well-controlled intermittent exotropia and was not at risk for amblyopia. Focus scores were highly sensitive for good focus but not specific. The PVS shows high sensitivity and specificity for detection of strabismus in adults. Future studies will determine whether this performance can be achieved in preschool children, who are at greatest risk for vision loss.
弱视是一种由双眼视轴不正(斜视)或在其他方面健康的眼睛出现离焦引起的视力损害形式。如果早期发现,这种情况可以得到完全治疗,但5岁以下患有弱视的儿童中超过一半未被发现。我们开发了一种儿童视力筛查仪(PVS)来检测弱视风险因素。该仪器会生成一个双眼视功能评分以表明视轴对齐情况,以及一个聚焦评分以表明聚焦情况。本研究的目的是通过对完全配合测试的成年人进行测试来评估PVS的性能。研究组包括40名年龄在22至79岁之间的受试者(20名对照者,20名患者)。12名患者患有恒定斜视(8至50三棱镜度),8名患者患有可变斜视(12至55三棱镜度)。所有对照者的双眼视功能评分均>50%。12名患者中有11名的双眼视功能评分<50%。双眼视功能评分>50%的患者患有控制良好的间歇性外斜视,不存在弱视风险。聚焦评分对良好聚焦具有高度敏感性,但不具有特异性。PVS在检测成年人斜视方面显示出高敏感性和特异性。未来的研究将确定在视力丧失风险最高的学龄前儿童中是否能达到这种性能。