使用动态钆喷酸葡胺扫描测量血脑屏障通透性——方法比较
Measurement of blood-brain barrier permeability using dynamic Gd-DTPA scanning--a comparison of methods.
作者信息
Larsson H B, Tofts P S
机构信息
Danish Research Centre of Magnetic Resonance, Hvidovre Hospital, Denmark.
出版信息
Magn Reson Med. 1992 Mar;24(1):174-6. doi: 10.1002/mrm.1910240119.
PMID:1556924
Abstract
Two recently published methods of blood-brain barrier permeability measurement using Gd-DTPA scanning are compared by authors representing each group. The physiological models are reconciled. Results from both groups agree. These show that the transfer constant (the permeability surface area product per unit volume of tissue) of the defective blood-brain barrier in multiple sclerosis is in the range 1-12.10(-4) s-1.
摘要
每组的作者对最近发表的两种使用钆-二乙三胺五乙酸（Gd-DTPA）扫描测量血脑屏障通透性的方法进行了比较。对生理模型进行了协调。两组的结果一致。这些结果表明，多发性硬化症中存在缺陷的血脑屏障的转运常数（每单位组织体积的通透表面积乘积）在1 - 12×10⁻⁴ s⁻¹范围内。
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