大鼠胶质瘤模型中辐射诱导的血脑屏障通透性变化的磁共振评估
MR assessment of radiation-induced blood-brain barrier permeability changes in rat glioma model.
作者信息
Krueck W G, Schmiedl U P, Maravilla K R, Spence A M, Starr F L, Kenney J
机构信息
Department of Radiology, University of Washington School of Medicine, Seattle 98195.
出版信息
AJNR Am J Neuroradiol. 1994 Apr;15(4):625-32.
PURPOSE
To assess the potential of a T1-weighted, gadolinium-enhanced MR technique for quantifying radiation-induced changes of blood-brain barrier permeability in a model of stereotactically implanted intracerebral gliomas in rats.
METHODS
We calculated the gadolinium blood-to-tissue transport coefficient for gadopentetate dimeglumine from signal intensities in sequential MR images in nine control animals that were not irradiated and in five and three animals that had received 2500 cGy and 1500 cGy whole-brain irradiation, respectively, at 2 days before imaging.
RESULTS
The average blood-to-tissue transport coefficient values were 9.76 mL.kg-1.min-1 in the control group, 23.41 mL.kg-1.min-1 in the 2500 cGy group, and 25.63 mL.kg-1.min-1 in the 1500-cGy group. Blood-to-tissue transport coefficients were significantly higher after irradiation, indicating increased radiation-induced blood-brain barrier permeability. Similar increased blood-brain barrier leakiness in brain tumors after high-dose irradiation has been shown by previous nuclear medicine studies using quantitative autoradiography.
CONCLUSION
Contrast-enhanced dynamic MR of brain gliomas is a sensitive method to document radiation-induced blood-brain barrier breakdown. Quantitative gadolinium-enhanced MR may become a useful tool for the management of patients with brain tumors undergoing radiation therapy.
目的
在大鼠立体定向植入脑胶质瘤模型中，评估一种T1加权、钆增强磁共振技术用于量化辐射诱导的血脑屏障通透性变化的潜力。
方法
我们根据9只未接受照射的对照动物以及分别在成像前2天接受2500 cGy和1500 cGy全脑照射的5只和3只动物的序列磁共振图像信号强度，计算钆喷酸葡胺的钆血-组织转运系数。
结果
对照组的平均血-组织转运系数值为9.76 mL·kg-1·min-1，2500 cGy组为23.41 mL·kg-1·min-1，1500 cGy组为25.63 mL·kg-1·min-1。照射后血-组织转运系数显著更高，表明辐射诱导的血脑屏障通透性增加。先前使用定量放射自显影的核医学研究已显示高剂量照射后脑肿瘤中血脑屏障渗漏也有类似增加。
结论
脑胶质瘤的对比增强动态磁共振成像 是记录辐射诱导的血脑屏障破坏的一种敏感方法。定量钆增强磁共振成像可能成为接受放射治疗的脑肿瘤患者管理的一种有用工具。
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