Kenney J, Schmiedl U, Maravilla K, Starr F, Graham M, Spence A, Nelson J
Department of Radiology, University of Washington School of Medicine, Seattle.
Magn Reson Med. 1992 Sep;27(1):68-75. doi: 10.1002/mrm.1910270108.
Sequential MR imaging with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) and sequential measurements of plasma Gd-DTPA concentration by inductively coupled plasma atomic emission spectroscopy (ICP-AES) were used to estimate the blood-to-tissue transport coefficient (Ki) in the 36B-10 rat glioma model. For these measurements, tissue Gd-DTPA concentration was estimated from tumor enhancement by correlation with calibration measurements obtained by ICP-AES analysis of tumor tissue. The 14 animals for which Ki was calculated can be grouped into those imaged at 11 days following tumor implantation, at 13-18 days, and at 20 days. The mean (+SEM) Ki values for these groups were 1.1 + 0.24, 9.2 + 0.8, and 13.4 + 1.7 ml/kg-min, respectively. These results correspond well with published data obtained by quantitative autoradiography. It is concluded that frequent sequential imaging and a graphical approach to Ki calculation are promising methods for determining the blood-to-tissue transport coefficient noninvasively by contrast-enhanced MRI.
采用钆喷酸葡胺（Gd-DTPA）进行序列磁共振成像，并通过电感耦合等离子体原子发射光谱法（ICP-AES）对血浆Gd-DTPA浓度进行序列测量，以估算36B-10大鼠胶质瘤模型中的血-组织转运系数（Ki）。对于这些测量，通过与肿瘤组织ICP-AES分析获得的校准测量值进行相关性分析，从肿瘤增强情况估算组织Gd-DTPA浓度。计算出Ki的14只动物可分为肿瘤植入后11天成像的动物、13 - 18天成像的动物以及20天成像的动物。这些组的平均（±标准误）Ki值分别为1.1±0.24、9.2±0.8和13.4±1.7 ml/kg-min。这些结果与通过定量放射自显影获得的已发表数据非常吻合。得出的结论是，频繁的序列成像和用于计算Ki的图形方法是通过对比增强MRI无创测定血-组织转运系数的有前景的方法。
