Bernal Giovanna M, Peterson Daniel A
Department of Neuroscience, The Chicago Medical School at, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Aging Cell. 2004 Dec;3(6):345-51. doi: 10.1111/j.1474-9728.2004.00132.x.
Neurogenesis occurs in two germinal centres of the adult brain and persists with increasing age, although at a reduced level. This observation, that the mature brain can support neurogenesis, has given rise to the hope that neural stem cells could be used to repair the brain by repopulating regions suffering from neuronal loss as a result of injury or disease. The aging brain is vulnerable to mild cognitive impairment, increasing incidence of stroke, and a variety of neurodegenerative diseases. However, most studies to date have focused on the young adult brain, and relatively little information is available about the regulation of neurogenesis in the aged brain or the potential of using neural stem cells to repair the aged brain. This review summarizes the current state of knowledge on neurogenesis in the young adult brain and discusses the information available on age-related changes in neurogenesis. Possible therapeutic strategies using neural stem cells for repair of the aging brain are considered.
神经发生在成人大脑的两个生发中心进行，并且随着年龄增长持续存在，尽管水平有所降低。成熟大脑能够支持神经发生这一观察结果，带来了一种希望，即神经干细胞可用于通过重新填充因损伤或疾病而遭受神经元损失的区域来修复大脑。衰老的大脑易受轻度认知障碍、中风发病率增加以及多种神经退行性疾病的影响。然而，迄今为止，大多数研究都集中在年轻成年大脑上，关于老年大脑中神经发生的调节或使用神经干细胞修复老年大脑的潜力的信息相对较少。本综述总结了目前关于年轻成年大脑中神经发生的知识状态，并讨论了有关神经发生与年龄相关变化的现有信息。还考虑了使用神经干细胞修复衰老大脑的可能治疗策略。
