成年哺乳动物的神经发生有多普遍？

How widespread is adult neurogenesis in mammals?

作者信息

Gould Elizabeth

机构信息

Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA.

出版信息

Nat Rev Neurosci. 2007 Jun;8(6):481-8. doi: 10.1038/nrn2147.

DOI:10.1038/nrn2147

PMID:17514200

Abstract

It is now widely accepted that neurogenesis occurs in two regions of the adult mammalian brain--the hippocampus and the olfactory bulb. There is evidence for adult neurogenesis in several additional areas, including the neocortex, striatum, amygdala and substantia nigra, but this has been difficult to replicate consistently other than in the damaged brain. The discrepancies may be due to variations in the sensitivity of the methods used to detect new neurons.

摘要

现在人们普遍认为，成年哺乳动物大脑的两个区域——海马体和嗅球——会发生神经发生。有证据表明，在包括新皮层、纹状体、杏仁核和黑质在内的其他几个区域也存在成年神经发生，但除了在受损大脑中，这一点很难得到一致的重复验证。差异可能是由于用于检测新神经元的方法的灵敏度不同。