Grases Felix, Isern Bernat, Perelló Joan, Sanchis Pilar, Prieto Rafel M
Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS), University of Balearic Islands, Palma of Mallorca, Spain.
Front Biosci. 2005 Jan 1;10:799-802. doi: 10.2741/1573.
Myo-inositol hexakisphosphate (InsP6, phytate) is a molecule to which diverse beneficial properties have been attributed. Some of these properties are related to its dermatological use as discolouring agent, on preventing calcinosis cutis or due to its important role on premature aging. Other studies also seem to demonstrate a capacity of InsP6 to inhibit skin cancer. In this paper, the effect of the vehicle of topical administration of phytate is studied, using four groups of male Wistar rats (n = 6) fed with an InsP6 defficient diet and treated with a hydrophyl gel or an O/W moisturizing cream with two different concentrations of InsP6. Due to the correlation between InsP6 absorption and its urinary excretion, these last values were used to evaluate this process. It was found that phytate was absorbed through the skin using both a gel or a cream, demonstrating that its absorption is independent on the matrix used for topical treatment. However, urinary InsP6 values were slightly higher when using the gel, but in all cases values were much higher than those found with oral InsP6 treatment, due to the formation of insoluble species in the gastrointestinal tract when InsP6 is administered orally.
肌醇六磷酸（InsP6，植酸）是一种具有多种有益特性的分子。其中一些特性与其作为脱色剂的皮肤科应用、预防皮肤钙质沉着或因其在早衰方面的重要作用有关。其他研究似乎也证明了InsP6具有抑制皮肤癌的能力。在本文中，研究了植酸局部给药载体的作用，使用四组雄性Wistar大鼠（n = 6），这些大鼠喂食缺乏InsP6的饮食，并分别用含有两种不同浓度InsP6的亲水凝胶或水包油保湿霜进行治疗。由于InsP6吸收与其尿排泄之间的相关性，最后这些数值被用于评估这一过程。结果发现，使用凝胶或乳膏时植酸均可经皮肤吸收，这表明其吸收与用于局部治疗的基质无关。然而，使用凝胶时尿InsP6值略高，但在所有情况下，这些值均远高于口服InsP6治疗时的值，这是因为口服InsP6时在胃肠道中会形成不溶性物质。
