Grases F, Isern B, Perelló J, Sanchis P, Prieto R M, Costa-Bauzà A
Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research, Faculty of Sciences, University of Balearic Islands, 07122 Palma de Mallorca, Spain.
Pharmazie. 2006 Jul;61(7):652.
In this paper, we present a pilot study of the absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans. We found that, after topical treatment with a 4% InsP6 rich gel, InsP6 urinary excretion increased 54% compared to the control situation (participants submitted to an InsP6-poor diet for 15 days, n = 6), clearly demonstrating that InsP6 is absorbed through the skin of humans. These results demonstrate the topical application as a suitable administration route of InsP6 in humans.
在本文中，我们展示了一项关于人皮肤对肌醇六磷酸（InsP6）吸收的初步研究。我们发现，在用富含4% InsP6的凝胶进行局部治疗后，与对照情况（参与者接受15天低InsP6饮食，n = 6）相比，InsP6的尿排泄量增加了54%，清楚地表明InsP6可通过人的皮肤吸收。这些结果证明局部应用是InsP6在人体中的一种合适给药途径。
