Khan Asad U, Krishnamurthy Shankarling
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002 India.
Front Biosci. 2005 Jan 1;10:866-72. doi: 10.2741/1580.
Covalent modifications of the amino-termini of the core histones in nucleosomes have been shown to be one of the key regulatory mechanisms in transcription regulation. Recently, new roles for histone modifications have been uncovered for the efficient functioning of RNA Pol II. Besides acetylation, which is the most characterized to date these modifications comprise phosphorylation, methylation, and ubiquitination. This review gives comprehensive view of all the major histone modifications and their effect on transcriptional regulation, in Saccharomyces cerevisiae.
核小体中核心组蛋白氨基末端的共价修饰已被证明是转录调控中的关键调节机制之一。最近，人们发现组蛋白修饰在RNA聚合酶II的有效功能中具有新的作用。除了乙酰化（这是迄今为止研究最多的修饰）外，这些修饰还包括磷酸化、甲基化和泛素化。本文综述了酿酒酵母中所有主要的组蛋白修饰及其对转录调控的影响。
