孕期暴露于环境烟草烟雾会促进成年期载脂蛋白E基因敲除小鼠（喂食普通饲料）的动脉粥样硬化发生及线粒体损伤。
Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet.
作者信息
Yang Zhen, Knight Cynthia A, Mamerow Madonna M, Vickers Kasey, Penn Arthur, Postlethwait Edward M, Ballinger Scott W
机构信息
Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, AL, USA.
出版信息
Circulation. 2004 Dec 14;110(24):3715-20. doi: 10.1161/01.CIR.0000149747.82157.01. Epub 2004 Nov 29.
BACKGROUND
Environmental tobacco smoke (ETS) exposure is recognized as a cardiovascular disease risk factor; however, the impact of prenatal ETS exposure on adult atherogenesis has not been examined. We hypothesized that in utero ETS exposure promotes adult atherosclerotic lesion formation and mitochondrial damage.
METHODS AND RESULTS
Atherosclerotic lesion formation, mitochondrial DNA damage, antioxidant activity, and oxidant load were determined in cardiovascular tissues from adult apolipoprotein E-/- mice exposed to either filtered air or ETS in utero and fed a standard chow diet (4.5% fat) from weaning until euthanasia. All parameters were significantly altered in male mice exposed in utero to ETS.
CONCLUSIONS
These data support the hypothesis that prenatal ETS exposure is sufficient to promote adult cardiovascular disease development.
背景
环境烟草烟雾（ETS）暴露被认为是心血管疾病的一个危险因素；然而，产前ETS暴露对成年期动脉粥样硬化形成的影响尚未得到研究。我们推测，子宫内ETS暴露会促进成年期动脉粥样硬化病变形成和线粒体损伤。
方法与结果
在成年载脂蛋白E基因敲除小鼠的心血管组织中测定动脉粥样硬化病变形成、线粒体DNA损伤、抗氧化活性和氧化负荷，这些小鼠在子宫内暴露于过滤空气或ETS中，并从断奶至安乐死期间喂食标准普通饲料（脂肪含量4.5%）。子宫内暴露于ETS的雄性小鼠的所有参数均发生了显著改变。
结论
这些数据支持以下假设，即产前ETS暴露足以促进成年期心血管疾病的发展。
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