Boss Andreas P, Maurer Thomas, Seiler Stefan, Aeschbach Armin, Hintermann Beat, Strebel Stephan
Department of Orthopedics, University Clinics, Kantonsspital, Spitalstrasse 21, 4031 Basel, Switzerland.
J Shoulder Elbow Surg. 2004 Nov-Dec;13(6):630-4. doi: 10.1016/j.jse.2004.04.005.
Shoulder surgery is often associated with severe postoperative pain. Previous results in which single or continuous subacromial infiltration of local anesthetics was used as a method of postoperative pain relief have been contradictory. This study was initiated to evaluate the postoperative analgesic effect of a subacromial continuous 0.25% bupivacaine infusion at a rate of 6 mL/h after elective open shoulder surgery. We hypothesized that this procedure would improve postoperative analgesia while reducing morphine requirements. By use of a prospective, double-blind, randomized study design, 50 consecutive patients undergoing acromioplasty and rotator cuff repair surgery received a multiorifice catheter placed in the subacromial space. Twenty patients received 0.25% bupivacaine (group 1), and twenty-two patients received saline solution (group 2). The primary endpoints in the two groups were total morphine consumption administered by patient-controlled analgesia and the patient's subjective pain level evaluated by a visual analog scale during the first 48 postoperative hours. No major technical or pharmacologic side effects were noticed, and the indwelling pain catheter was well tolerated by all patients. There was no statistically significant difference (P < .05) either in total cumulative morphine consumption microg/48 h (73.2 +/- 43.1 vs 60.9 +/- 35.9) or in subjective pain perception 10-point visual analog scale (3.2 +/- 1.4 vs 3.1 +/- 1.5) between the two study groups. The continuous subacromial infiltration of 0.25% bupivacaine at a rate of 6 mL/h is concluded to be ineffective in providing pain relief supplementary to patient-controlled analgesia after open rotator cuff repair and acromioplasty surgery.
肩部手术常常伴有严重的术后疼痛。以往使用单次或持续肩峰下局部麻醉药浸润作为术后疼痛缓解方法的结果相互矛盾。本研究旨在评估择期开放性肩部手术后以6 mL/h的速率持续肩峰下输注0.25%布比卡因的术后镇痛效果。我们假设该方法可改善术后镇痛效果,同时减少吗啡用量。通过前瞻性、双盲、随机研究设计, 50例连续接受肩峰成形术和肩袖修复手术的患者在肩峰下间隙置入多孔导管。20例患者接受0.25%布比卡因(第1组),22例患者接受生理盐水(第2组)。两组的主要终点指标为术后48小时内患者自控镇痛给予的吗啡总用量,以及采用视觉模拟评分法评估的患者主观疼痛程度。未观察到重大技术或药物副作用,所有患者对留置的镇痛导管耐受性良好。两组间在吗啡总累积用量(微克/48小时)(73.2±43.1 对比60.9±35.9)或主观疼痛感受(10分视觉模拟评分法)(3.2±1.4对比3.1±1.5)方面均无统计学显著差异(P<0.05)。得出结论,在开放性肩袖修复和肩峰成形术后,以6 mL/h的速率持续肩峰下浸润0.25%布比卡因对患者自控镇痛起辅助镇痛作用无效。