Gohel M S, Barwell J R, Wakely C, Minor J, Harvey K, Earnshaw J J, Heather B P, Whyman M R, Poskitt K R
Department of Vascular Surgery, Cheltenham General Hospital, GL53 7AN Gloucestershire, UK.
Eur J Vasc Endovasc Surg. 2005 Jan;29(1):78-82. doi: 10.1016/j.ejvs.2004.09.016.
Previous studies have suggested that perforating vein incompetence is reduced by surgery to superficial veins. This study analysed the effect in a randomised clinical trial.
Retrospective analysis of duplex data.
Patients in this study were part of the ESCHAR randomised controlled trial. All patients had chronic venous leg ulceration with superficial venous reflux. Patients were treated with compression bandaging alone or compression plus superficial venous surgery. Legs were assessed using colour venous duplex prior to treatment and at 3 and 12 months.
Of 500 patients recruited to the ESCHAR trial, 261 were included in this study. One hundred and forty six of 261 legs were treated with compression alone and 115/261 underwent compression and superficial venous surgery. In the compression group, more legs had incompetent perforators at 12 months (77/131) compared to baseline (61/146, p =0.010, Wilcoxon Signed Ranks test for paired data in 131 legs). Following surgery, significantly fewer legs had incompetent calf perforators (59/115 vs 44/104 at 12 months, p =0.001, Wilcoxon Signed Ranks test for paired data in 104 legs). In addition, significantly fewer legs in the compression and surgery group developed new perforator incompetence in comparison to the group treated with compression alone (12/104 vs 36/131, p =0.003, Chi-Squared test).
Surgical correction of superficial reflux may abolish incompetence in some calf perforators and offer protection against developing new perforator incompetence.
既往研究表明,对浅静脉进行手术可减轻交通静脉功能不全。本研究在一项随机临床试验中分析了其效果。
对双功超声数据进行回顾性分析。
本研究中的患者是ESCHAR随机对照试验的一部分。所有患者均患有慢性下肢静脉溃疡并伴有浅静脉反流。患者接受单纯加压包扎或加压包扎加浅静脉手术治疗。在治疗前以及治疗后3个月和12个月时,使用彩色静脉双功超声对下肢进行评估。
ESCHAR试验招募的500例患者中,261例纳入本研究。261条下肢中,146条仅接受加压包扎治疗,115条接受了加压包扎和浅静脉手术。在加压包扎组中,与基线相比,12个月时更多下肢存在功能不全的交通静脉(77/131比61/146,p = 0.010,对131条下肢的配对数据进行Wilcoxon符号秩检验)。手术后,小腿交通静脉功能不全的下肢明显减少(12个月时59/115比44/104,p = 0.001,对104条下肢的配对数据进行Wilcoxon符号秩检验)。此外,与单纯接受加压包扎治疗的组相比,加压包扎加手术组出现新的交通静脉功能不全的下肢明显更少(12/104比36/131,p = 0.003,卡方检验)。
浅静脉反流的手术矫正可能消除一些小腿交通静脉的功能不全,并预防新的交通静脉功能不全的发生。