[抑郁症患者情绪加工的变化：一项使用带有情感内容图片的功能磁共振断层扫描研究]
[Changes in the emotional processing in depressive patients: a study with functional magnetoresonance tomography under the employment of pictures with affective contents].
作者信息
Wagner Verena, Müller Jürgen L, Sommer Monika, Klein Helmfried E, Hajak Göran
机构信息
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg.
出版信息
Psychiatr Prax. 2004 Nov;31 Suppl 1:S70-2. doi: 10.1055/s-2004-828410.
OBJECTIVE
The influence of emotional contents on brain activation was examined using functional magnetic resonance tomography (fMRT).
METHOD
Aquiring 100 EPI-measurements of the whole brain, series of positive and negative pictures from the International Affective Picture System (IAPS) were shown to eight depressed males and to healthy controls.
RESULTS
In depression, there was an overactivation in hippocampal area during positive stimulation, whereas an overactivation of amygdala, orbital and prefrontal regions was seen during negative stimulation.
CONCLUSIONS
These results emphasize the importance of functional interaction between the neural network associated with emotion. We could show that depression is connected to dysregulation and disturbed functional connectivity during emotional processing.
目的
使用功能磁共振断层扫描（fMRT）研究情绪内容对大脑激活的影响。
方法
对八名抑郁症男性和健康对照者展示国际情感图片系统（IAPS）中的一系列正性和负性图片，同时获取全脑100次回波平面成像（EPI）测量数据。
结果
在抑郁症患者中，正性刺激期间海马区过度激活，而负性刺激期间杏仁核、眶部和前额叶区域过度激活。
结论
这些结果强调了与情绪相关的神经网络之间功能相互作用的重要性。我们可以证明，抑郁症与情绪加工过程中的调节失调和功能连接紊乱有关。
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