双环[n.1.0]烷烃的偕二氟环丙胺衍生物的合成与性质
Synthesis and properties of gem-(difluorocyclopropyl)amine derivatives of bicyclo[n.1.0]alkanes.
作者信息
Nowak Ireneusz, Cannon John F, Robins Morris J
机构信息
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700, USA.
出版信息
Org Lett. 2004 Dec 9;6(25):4767-70. doi: 10.1021/ol047943b.
PMID:15575681
Abstract
[reaction: see text] Generation of difluorocarbene(carbenoid) in the presence of enamines derived from cyclic ketones results in overall insertion of CF2 to produce bicyclic difluorocyclopropylamines. These adducts are very weakly basic, and their thermal stabilities vary markedly with their structures.
摘要
[反应：见正文] 在由环酮衍生的烯胺存在下生成二氟卡宾（类卡宾）会导致CF₂整体插入，从而生成双环二氟环丙胺。这些加合物碱性非常弱，并且它们的热稳定性随结构的不同而有显著差异。
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