通过连续氮杂 Henry 加成/环化复分解反应对映选择性合成-β-和-β-环庚基氟代胺。
Enantioselective Synthesis of - and -Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis.
机构信息
Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
出版信息
Org Lett. 2023 Feb 17;25(6):950-955. doi: 10.1021/acs.orglett.2c04285. Epub 2023 Feb 3.
Abstract
The synthesis of 7-membered carbocyclic β-fluoroamines is accomplished by a combination of the enantioselective aza-Henry reaction of aliphatic -Boc imines and ring-closing metathesis. Use of reductive denitration gives both diastereomers of the β-fluoro amine carbocycle, each with high enantiomeric excess.
摘要
通过脂肪族 Boc 亚胺的对映选择性氮杂 Henry 反应和闭环复分解反应的组合，完成了 7 元碳环 β-氟代胺的合成。还原脱氮的使用得到了β-氟代胺碳环的两种非对映异构体，每个都具有高对映过量。
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