Departamento de Química Orgánica y Farmacéutica. Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Chem Soc Rev. 2011 Jul;40(7):3445-54. doi: 10.1039/c1cs15018a. Epub 2011 Apr 11.
In the current bid for synthetic efficiency, multiple bond-forming transformations are becoming a key concept in organic synthesis. In this context, domino protocols have become increasingly common in the synthesis of bicyclic systems. This tutorial review aims at providing a short but authoritative overview of this topic, focusing on the preparation of bridged bicyclo[n.3.1]alkane systems, and is organized according to the number of rings created in the key domino process.
在当前追求合成效率的背景下，多步成键转化已成为有机合成的一个关键概念。在此背景下，串联反应在双环体系的合成中变得越来越普遍。本综述旨在提供该主题的简短而权威的概述，重点介绍桥环双环[n.3.1]烷烃体系的制备方法，并根据关键串联反应中形成的环数进行组织。
