Coles M-L Chantal, Brennan Noel A, Shuley Vicki, Woods Jill, Prior Chris, Vehige Joseph G, Simmons Peter A
Brennan Consultants Pty Ltd, 110 Auburn Road, Auburn Village, Melbourne, VIC, 3122, Australia.
Clin Exp Optom. 2004 Nov;87(6):367-71. doi: 10.1111/j.1444-0938.2004.tb03096.x.
Daily disposable contact lenses are considered to be the pinnacle of safe contact lens wear, yet it has been suggested that it takes some period of wear for the lens surface to reach optimal compatibility with the ocular surface. This study assesses the influence of brief treatment with a conditioning drop on the ocular response to new contact lenses over a single day of wear.
The study was a single-masked, paired (contralateral) comparison of the signs and symptoms with wear of new Acuvue 2 contact lenses pretreated with a conditioning agent containing carboxymethylcellulose (carmellose, CMC) against new lenses inserted directly from the blister pack. Sixty-one subjects participated in the study, of whom 59 were considered eligible for data analysis. Subjects were also divided into symptomatic and asymptomatic lens wearers based on their overall comfort level in lens wear. Symptoms and signs were recorded at lens delivery and following eight hours of wear.
A set of slitlamp signs, comprising corneal staining (p <0.05), limbal redness (p <0.05), bulbar conjunctival hyperaemia (p <0.05), bulbar conjunctival staining (p <0.01) and palpebral conjunctival redness (p <0.05) showed small but statistically significant (p <0.05) end-of-day mean values in favour of the lens that was conditioned with the rewetting agent. These data were supported by the proportion of subjects showing lower gradings with conditioned lenses versus unconditioned lenses, as follows: corneal staining (35 per cent versus 12 per cent, p <0.05), limbal redness (43 per cent versus 22 per cent, p <0.05), bulbar conjunctival hyperaemia (50 per cent versus 15 per cent, p <0.05), bulbar conjunctival staining (46 per cent versus 30 per cent, p <0.1) and palpebral conjunctival hyperaemia (28 per cent versus 17 per cent, NS). For those subjects reporting symptoms with lens wear (n=12), there was a statistically significant (p <0.05) preference in terms of comfort as a result of preconditioning.
The results of the investigation suggest that use of a conditioning agent can provide a more physiologically suitable environment for a new lens, thereby reducing the clinical signs associated with lens discomfort. The protocol used here, which is based on a statistical paradigm using standard pictorial grading scales, allows high sensitivity in detecting small changes in ocular parameters.
日抛型隐形眼镜被认为是安全佩戴隐形眼镜的极致产品，但有观点认为，镜片表面需要经过一段时间的佩戴才能与眼表达到最佳兼容性。本研究评估了使用润眼液进行短暂处理对佩戴新隐形眼镜一天后眼部反应的影响。
本研究为单盲、配对（对侧）比较，比较使用含羧甲基纤维素（羟丙甲纤维素，CMC）的润眼液预处理的新视康2隐形眼镜与直接从泡罩包装中取出的新镜片佩戴时的体征和症状。61名受试者参与了研究，其中59名被认为符合数据分析条件。受试者还根据佩戴镜片时的总体舒适度分为有症状和无症状的隐形眼镜佩戴者。在镜片交付时和佩戴8小时后记录症状和体征。
一组裂隙灯检查体征，包括角膜染色（p<0.05）、角膜缘发红（p<0.05）、球结膜充血（p<0.05）、球结膜染色（p<0.01）和睑结膜发红（p<0.05），显示使用润眼液处理的镜片在一天结束时的平均数值虽小但具有统计学意义（p<0.05）。以下是使用处理过的镜片与未处理的镜片相比分级较低的受试者比例，这些数据支持了上述结果：角膜染色（35%对12%，p<0.05）、角膜缘发红（43%对22%，p<0.05）、球结膜充血（50%对15%，p<0.05）、球结膜染色（46%对30%，p<0.1）和睑结膜充血（28%对17%，无显著性差异）。对于那些报告佩戴镜片有症状的受试者（n=12），预处理后在舒适度方面有统计学意义的显著偏好（p<0.05）。
研究结果表明，使用润眼液可为新镜片提供更符合生理的适宜环境，从而减少与镜片不适相关的临床体征。这里使用的方案基于使用标准图片分级量表的统计范式，在检测眼部参数的微小变化方面具有高灵敏度。
