Wu Kana, Hu Frank B, Fuchs Charles, Rimm Eric B, Willett Walter C, Giovannucci Edward
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA.
Cancer Causes Control. 2004 Nov;15(9):853-62. doi: 10.1007/s10552-004-1809-2.
Examining the effects of dietary patterns on cancer risk may provide insights beyond the assessment of individual foods or nutrients.
In the health professionals follow-up cohort, associations between the 'prudent' and the 'western' dietary pattern and risk of colon cancer and adenomas were examined in 561 colon cancer cases and 1207 distal colon adenoma cases.
Higher prudent pattern scores were only weakly and non-significantly associated with decreased risk of colon cancer or distal colon adenoma (highest versus lowest quintile: colon cancer: multivariate adjusted relative risk (RR) = 0.84 (95% confidence interval (CI) = 0.64-1.10); p(trend) = 0.37; distal adenoma: multivariate odds ratio (OR) = 0.88 (95% CI = 0.73-1.08); p(trend) = 0.12). Our findings suggest a moderately increased risk of colon cancer and distal adenoma with higher western pattern scores (colon cancer: RR = 1.27 (95% CI = 0.96-1.69), p(trend) = 0.05; distal adenoma: OR = 1.28 (95% CI = 1.05-1.56), p(trend) = 0.01). Adding body mass index, which is positively related to western pattern and thus may be considered an intermediate endpoint between western pattern and colon cancer, attenuated associations somewhat but not substantially.
Our data do not provide evidence for an appreciable inverse association between higher prudent pattern scores and risk of colon cancer or distal colon adenomas, but do support a moderate positive association between higher western pattern scores and risk of colon cancer or distal colon adenomas.
研究饮食模式对癌症风险的影响可能会提供超出对单一食物或营养素评估的见解。
在健康专业人员随访队列中，对561例结肠癌病例和1207例远端结肠腺瘤病例，研究了“谨慎”和“西方”饮食模式与结肠癌及腺瘤风险之间的关联。
较高的谨慎模式得分与结肠癌或远端结肠腺瘤风险降低仅呈微弱且无显著意义的关联（最高五分位数与最低五分位数相比：结肠癌：多变量调整相对风险（RR）=0.84（95%置信区间（CI）=0.64 - 1.10）；p趋势=0.37；远端腺瘤：多变量比值比（OR）=0.88（95%CI = 0.73 - 1.08）；p趋势=0.12）。我们的数据表明，较高的西方模式得分与结肠癌和远端腺瘤风险适度增加相关（结肠癌：RR = 1.27（95%CI = 0.96 - 1.69），p趋势=0.05；远端腺瘤：OR = 1.28（95%CI = 1.05 - 1.56），p趋势=0.01）。加入与西方模式呈正相关且因此可被视为西方模式与结肠癌之间中间终点的体重指数后，关联有所减弱但幅度不大。
我们的数据未提供证据表明较高谨慎模式得分与结肠癌或远端结肠腺瘤风险之间存在明显的负相关，但确实支持较高西方模式得分与结肠癌或远端结肠腺瘤风险之间存在适度正相关。
