精液中的HIV病毒脱落：与全身病毒特异性CD8反应缺乏相关性。
HIV viral shedding in semen: lack of correlation with systemic virus-specific CD8 responses.
作者信息
Sheth Prameet M, Shahabi Kamnoosh, Rebbapragada Anuradha, Kovacs Colin, Dimayuga Rowena, Chackalakkal Sharon, MacDonald Kelly, Mazzulli Tony, Kaul Rupert
机构信息
Department of Medicine, University of Toronto, Toronto, Canada.
出版信息
AIDS. 2004 Nov 5;18(16):2202-5. doi: 10.1097/00002030-200411050-00015.
Semen is a major transmission vector for HIV. Virus-specific CD8 T cells are critical in HIV control, but their relationship with semen viral load is unknown. We therefore examined the association between systemic HIV-specific IFN-gamma CD8 responses and viral load in the semen and blood of HIV-infected men. No correlation was observed between viral load in either semen or blood and systemic CD8 T-cell responses. Further studies of immune correlates of semen HIV shedding are needed.
精液是艾滋病毒的主要传播载体。病毒特异性CD8 T细胞在控制艾滋病毒方面至关重要，但其与精液病毒载量的关系尚不清楚。因此，我们研究了艾滋病毒感染男性的全身艾滋病毒特异性干扰素-γ CD8反应与精液和血液中病毒载量之间的关联。在精液或血液中的病毒载量与全身CD8 T细胞反应之间未观察到相关性。需要对精液艾滋病毒脱落的免疫相关性进行进一步研究。
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