Sheppard William M, Wanamaker Hayes H, Pack Adam, Yamamoto Satoshi, Slepecky Norma
Department of Otolaryngology/Communicative Disorders Unit, SUNY Upstate Medical University at Syracuse, New York, USA.
Otolaryngol Head Neck Surg. 2004 Dec;131(6):890-6. doi: 10.1016/j.otohns.2004.05.021.
To evaluate patterns of ototoxic damage sustained from gentamicin applied directly to the round window in varying delivery vehicles.
The search for a reliable method of drug delivery to the inner ear continues. Vehicles such as Gelfoam, hyaluronic acid, and fibrin may allow for a more reproducible pattern of ototoxic damage.
Histological evaluation of vestibular and cochlear damage was performed on Mongolian gerbils after a known dosage of gentamicin in different delivery vehicles.
Variable ototoxic damage was caused by Gelfoam and fibrin-based vehicles. No ototoxic damage was found in the Healon vehicle. The vehicle of fibrin and Gelfoam combined resulted in severe damage. There was no evidence of selective cochlear or vestibular ototoxicity in any of the vehicles tested.
The fibrin/Gelfoam vehicle was the only delivery system to produce reliable damage. Ototoxic damage depended on the vehicle. We found no evidence for selective vestibular ototoxicity with gentamicin.
评估庆大霉素通过不同给药载体直接作用于圆窗所导致的耳毒性损伤模式。
寻找一种可靠的内耳给药方法的研究仍在继续。诸如明胶海绵、透明质酸和纤维蛋白等载体可能会导致更可重复的耳毒性损伤模式。
在给蒙古沙鼠使用已知剂量的不同给药载体的庆大霉素后，对其前庭和耳蜗损伤进行组织学评估。
明胶海绵和纤维蛋白基载体导致了不同程度的耳毒性损伤。在透明质酸钠载体中未发现耳毒性损伤。纤维蛋白和明胶海绵联合载体导致了严重损伤。在任何测试载体中均未发现选择性耳蜗或前庭耳毒性的证据。
纤维蛋白/明胶海绵载体是唯一能产生可靠损伤的给药系统。耳毒性损伤取决于载体。我们没有发现庆大霉素存在选择性前庭耳毒性的证据。
